Mast cell proteases as modulators of the glial scar to promote neuroregeneration after trauma. Hasselt University
Axon regeneration after trauma in the mammalian adult central nervous system (CNS) is restricted due to numerous factors, such as the lack of growth-promoting factors, the low intrinsic capacity of neurons to survive from damage and, most importantly, the presence of growth-inhibitory factors. The most potent inhibitory components in the damaged CNS are molecules of the extracellular matrix (ECM), such as chondroitin sulphate proteoglycans ...