Projects
Synthetic organogenesis: using in vivo cellular reprogramming to induce ectopic organs KU Leuven
Our long-term goal is to find ways to induce synthetic organogenesis, that is to produce miniorgans that function in vivo. With the term "miniorgan" we mean multicellular assemblies that i) contain all major cell types normally present in an organ, ii) that show morphological organization within the miniorgan, and iii) that functionally integrate into the host tissue. Thus, miniorgans may be smaller than regular organs, but they are fully ...
Discovering a novel anti-cancer mechanism: How YAP-driven regeneration eliminates liver cancer. KU Leuven
Cancer cells and cancer treatments, such as radiation- and chemotherapy, can cause severe injury to the affected organ. The team of Professor Halder is thus investigating how cancerous livers can be stimulated to better heal and repair defects caused by the cancer and/or by chemotherapy. They are testing whether experimental activation of an organ repair program can promote liver repair and help the liver to maintain its vital function for ...
Interreg project "Memories". University of Antwerp
Effect of iron status and red cell indices on exercise capacity and response of exercise training University of Antwerp
Biomarkers in first-void urine for improved diagnosis and monitoring University of Antwerp
Cell-associated HIV RNA as a superior marker of treatment success or failure. University of Antwerp
DOT1l in Osteoarthritis: The DOTOS project will study the role of DOT1L in synovial joint development, homeostasis and disease with specific attention towards osteoarthritis (OA), KU Leuven
The DOTOS project will study the role of DOT1L in synovial joint development, homeostasis and disease with specific attention towards osteoarthritis (OA), one of the most common chronic diseases.
We identified an association between the DOT1L (DOT1-like histone H3 methyltransferase) gene and OA. Histone methylation is a regulator of gene transcription. Some histone methylations result in increased gene expression, e.g. lysine ...