Projects
The Interprosthetic Gap as a Risk Factor for Interprosthetic Fractures of the Femur KU Leuven
An interprosthetic (IP) gap is created when an arthroplasty is performed on both joints of the same bone to replace deteriorated joints. Specifically in this
thesis, placement of a hip and knee prosthesis in the femur was examined. Such an ipsilateral placement of stemmed prostheses into the same bone creates a gap of varying size and location depending on the prosthesis stem lengths. The IP gap is measured in between the tips of the ...
The chicken cerebellum as a model to study the impact of monocarboxylate transporter 8 deficiency on early brain development KU Leuven
Thyroid hormones (THs) have been characterised as important regulatory factors of vertebrate brain development. As such, they contribute to a wide variety of neurodevelopmental processes that depend on adequate TH levels as well as a correct timing of TH access to distinct neural cells in order to obtain a fully functional brain. This strict regulation of local TH availability is the result of a complex interplay between TH transporters ...
Heme oxygenase-1 and chronic kidney disease: A translational study of oxidative stress and atherogenesis KU Leuven
In advanced kidney disease the prevalence of atherosclerotic cardiovascular disease is high and nearly equivalent across age groups. Recent data indicate that even minor renal dysfunction impacts on the onset of cardiovascular disease (CVD). Many authors hypothesize that increased oxidative stress is the unifying concept that initiates and feeds this problem. Several findings in uremic patients point towards an imbalance favoring the ...
Translational Molecular Imaging Program for the University of Antwerp: application driven preclinical research. University of Antwerp
Novel insights in the HPA-axis during critical illness KU Leuven
Critical illness is defined as any condition that requires support of failing vital organ functions, without which death would rapidly ensue. As such, it represents an extreme example of physical stress, where stress comprises the normal physical response of the human body that ariseswhen confronted with a threat. In healthy individuals, experiencing stress causes an immediate activation of the hypothalamic-pituitary-adrenalaxis, which ...