Structural Biology of the Human Androgen Receptor for next generation drug design KU Leuven
The aim of this PhD project is to elucidate the mechanism of action of a novel class of human androgen receptor antagonists (MEL6), which were recently discovered in the KU Leuven Molecular Endocrinology Laboratory. Fragments of the human androgen receptor will be expressed in and purified to high purity from E. coli and utilized for crystallization experiments. While the structures of agonist complexes are already available, all efforts have ...