Projects
Microglia and neuroinflammation: transducers of amyloid beta toxicity in human Alzheimer’s disease KU Leuven
Alzheimer’s disease (AD) is a chronic neurodegenerative disease and is the most common form of dementia worldwide. AD is characterized by the build up of abnormal protein, in the form of amyloid beta plaques and tau tangles. AD is accompanied by changes in the immune cells of the brain, the microglia. This inflammation in the brain is referred to as neuroinflammation, which may be a simple consequence of damage to nerve cells or may ...
Head impact biomechanics for protecting the active ageing population KU Leuven
In Europe, the incidence of fatal and hospitalized traumatic brain injury (TBI) is 262/100.000/year. Lately, a significant increase in the proportion of elderly patients suffering TBI has been observed. This can be explained by changing demographics, better health status allowing them to remain fully active, but also by the presumed mechanical vulnerability of the ageing brain and surrounding tissues.
While staying active is rightfully ...
The scourge of unverified and spurious "penicillin allergy": a preventable clinical and public health menace. University of Antwerp
Exploring the role of Aβ, Tau and Tau modulators in inducing neuronal death in a novel humanized mouse model for Alzheimer Disease KU Leuven
Neuronal cell loss is an ultimate hallmark of the many neurodegenerative diseases including Alzheimer’s disease (AD). However, neuronal cell death phenotype is seldom investigated. In AD, the relationship between Amyloid β (Aβ) peptide, Tau, and neuronal death is a central problem. Nevertheless, cell culture or animal models do not reproduce well the cell death phenotype that is crucial to analyze this relation. As it remains unclear to what ...