Functional characterisation of gut mast cells in irritable bowel syndrome. University of Antwerp
Irritable bowel syndrome (IBS) is a common yet difficult to treat chronic disorder characterized by abdominal pain combined with diarrhea and/or constipation. Mast cells are tissue-resident immune cells which are involved In the pathophysiology of IBS by activating and sensitizing sensory nerves endings, but the mechanisms and mediators involved are unknown. We aim to study these mast cells using a novel culture model developed by the Laboratory ...