Welcome Trail: improving weight control and CO-morbidities in children with obesity via executive function training. University of Antwerp
Genome and transcriptome engineering with CRISPR/Cas as a precision medicine for Charcot-Marie-Tooth type 2L. University of Antwerp
Improving current cancer detection and treatment follow up through the development of next generation cancer assays. University of Antwerp
Improved decision-making for coordinating breast cancer screening Ghent University
The high uncertainty and complexity to harmonize the different stages of a care pathway entangles the coordination between demand and resources in breast cancer screening resulting in unpredictable throughput times and patient dissatisfaction. In order to devise an accurate planning of patients and allocation of capacity, we propose an integrated methodology to improve the operational decision-making and support policy development.
A neurocognitive approach to the Self in Autism Spectrum Disorder Ghent University
Autism Spectrum Disorder (ASD) is a prevalent neurodevelopmental disorder, characterized by social difficulties. Research trying to explain these difficulties has focused mostly on problems with understanding others, but there are indications that the U+2018se
Towards a more comprehensive understanding of catecholaminergic consequences in dynamic network topology and salience processing Ghent University
The network structure and organisation of the human brain has become of increasing interest to the neuroscientific community. Here, the brain can be viewed as a system with various interacting regions that produce complex behaviours. Previous work has sho
Elucidating the role of macrophages in liver regeneration and tissue unit formation Ghent University
The liver has the unique ability to rapidly regenerate and restore function following tissue damage. This has been recognized as far back as the ancient Greeks, who described it in the myth of Prometheus. However, the precise mechanisms controlling regene
Investigating the effects of regulatory phosphorylation and linear ubiquitination on Pyrin-mediated auto-inflammatory disorders. Ghent University
Enhanced inflammasome signaling due to Pyrin mutations underlie auto-inflammation in Familial Mediterranean Fever (FMF). We obtained evidence that also Otulin-related auto-inflammatory syndrome (ORAS) involves enhanced Pyrin signaling. In this project, we will investigate the mechanisms by which Pyrin signaling is regulated by phosphorylation and linear ubiquitination, and how this modulates Pyrin-mediated auto-inflammation in FMF and ORAS ...
We recently discovered TIE1 and TIE2 receptor signaling on kidney glomerular podocytes, which are important cells of the glomerular filtration barrier. To investigate if TIE-receptors regulate glomerular integrity, we will investigate the role of this signaling system on podocyte function, i.e. survival, migration, proliferation and permeability. In addition, we will investigate the downstream
signaling pathways regulated by ...