Oriented covalent coupling of site-specific modified nanobodies onto functionalized conjugated polymers using 'click chemistry' Hasselt University
The quality of many biosurface applications, including biosensing systems relies on the resulting physicochemical properties of the biomolecules after immobilization on the surface. The sensitivity and selectivity of such systems are directly related to the accessibility and activity, determined by the orientation, of the immobilized biomolecules. It is well known that immobilization by physical adsorption leads to a weak reproducibility. In the ...