Elucidating the role of alternative trans-splicing in the mRNA abundance regulation of Leishmania. University of Antwerp
Leishmania is a genus of protozoan parasites that cause the disease leishmaniasis in humans and a wide array of vertebrate animals. The parasite exhibits a remarkable gene expression system where genes lack individual RNA polymerase II promoters and are therefore not individually controllable by transcription factors. Instead, genes are transcribed constitutively in long polycistronic units of functionally unrelated genes and ...