Exploring the endocytic route of ICAM-5 in hippocampal neurons - a strategy to reveal the gamma-secretase independent role of presenilin 1 in protein trafficking. KU Leuven
Mechanisms that regulate intracellular membrane/protein trafficking are of utmost physiological importance. By affecting the delivery of macromolecules to specific external and subcellular sites they impact majority, if not all relevant cellular processes. Not surprisingly, defects in intracellular membrane flow and its regulators are observed in many pathological conditions, including several neurodegenerative disorders (Howell et al., 2006; ...