Projects
Optimization of cathodes for solid state batteries by insights in the interaction between cathode and solid electrolyte Hasselt University
Application of novel organic reactions for the preparation of new heteroaromatic scaffolds KU Leuven
N-containing heterocycles can be found in several bioactive small molecules, and it is well known that these are very prominent scaffolds in drug discovery. Additionally, the availability of organic reactions for different functionalizations is the key factor that may be limiting the development of new drugs. It is widely accepted that investments in basic chemistry for the development of new synthetic methodologies towards heterocycles are ...
A modular and streamlined synthetic platform for diverse polyheterocyclic libraries. KU Leuven
Drug discovery is a lengthy, expensive, difficult, and inefficient process with quite a low rate of new therapeutic discoveries from existing molecules or new molecular entities. These projects generally start with a high-throughput screening campaign of commercially available compound libraries
against the target of interest. However in recent years, it became clear that current combinatorial libraries are not enough. As a mission of ...
Development of polyoxometaltes as artificial enzymes for the selective hydrolysis of membrane- and glyco -proteins for proteomics applications KU Leuven
The total number of different proteins present in Earth organisms is estimated to be up to 10 million. While their identification in terms of primary sequences is expanding at an increasing rate, elucidation of their function and three-dimensional structure is drastically lacking behind. Most of the currently used approaches in proteomics for unraveling the structure and function of proteins require protein hydrolysis into more manageable ...
New avenues for small heterocycles: Expanding the horizon of intra-/inter-molecular trapping of in situ generated transient -alkyl-/vinyl-palladium(II) species. KU Leuven
Transition metal catalysis lies at the heart of modern innovative science. To expand this area in organic synthesis, the challenge is to identify novel strategies for the formation of organo-metallic intermediates under mild conditions, and to discover new methods for their subsequent transformation. In this proposal we will focus on the trapping of transient C(sp3)- and C(sp2)-Pd species via C-H activation, or employing oxygen/nitrogen ...
Paramagnetic species in catalysis research. A unified approach towards heterogeneous, homogeneous and enzyme catalysis (PARACAT). University of Antwerp
The DUBBLE Beam Lines at the ESRF: Extremely brilliant Xrays for revealing the structure and function of atoms, molecules and materials Hasselt University
Understanding the design, synthesis and properties of novel Na ion conducting electrolytes. Hasselt University
Nonlinear optical characterisation of crystal growth KU Leuven
Crystallization is of crucial importance in the synthesis, separation and purification of high-end materials in the chemical and pharmaceutical industry. In spite the importance of crystallization, the knowledge about the mechanisms that lead to crystal growth are not well known.
To understand the different stages of crystallization, different techniques were developed based on harmonic scattering. Various properties such as ...