Projects

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Paramagnetic species in catalysis research. A unified approach towards heterogeneous, homogeneous and enzyme catalysis (PARACAT). University of Antwerp

Sabine Van Doorslaer
Center for Ethics, Organic synthesis (ORSY), Biophysics and Biomedical Physics
PARACAT aims at educating a group of young researchers to implement methods for cutting edge research in the field of catalysis, comprehensively exploring for the first time the role of open-shell species, an innovative area at the intersections between chemistry, physics and biology. The programme puts strong emphasis on ethics and social reflections by combining the scientific expertise of (bio)chemists, (bio)physicists and industrial partners ...

Application of novel organic reactions for the preparation of new heteroaromatic scaffolds KU Leuven

Wim Dehaen
Molecular Design and Synthesis

N-containing heterocycles can be found in several bioactive small molecules, and it is well known that these are very prominent scaffolds in drug discovery. Additionally, the availability of organic reactions for different functionalizations is the key factor that may be limiting the development of new drugs. It is widely accepted that investments in basic chemistry for the development of new synthetic methodologies towards heterocycles are ...

A modular and streamlined synthetic platform for diverse polyheterocyclic libraries. KU Leuven

Erik Van der Eycken
Molecular Design and Synthesis

Drug discovery is a lengthy, expensive, difficult, and inefficient process with quite a low rate of new therapeutic discoveries from existing molecules or new molecular entities. These projects generally start with a high-throughput screening campaign of commercially available compound libraries

against the target of interest. However in recent years, it became clear that current combinatorial libraries are not enough. As a mission of ...

Development of polyoxometaltes as artificial enzymes for the selective hydrolysis of membrane- and glyco -proteins for proteomics applications KU Leuven

Tatjana Vogt
Molecular Design and Synthesis

The total number of different proteins present in Earth organisms is estimated to be up to 10 million. While their identification in terms of primary sequences is expanding at an increasing rate, elucidation of their function and three-dimensional structure is drastically lacking behind. Most of the currently used approaches in proteomics for unraveling the structure and function of proteins require protein hydrolysis into more manageable ...

New avenues for small heterocycles: Expanding the horizon of intra-/inter-molecular trapping of in situ generated transient -alkyl-/vinyl-palladium(II) species. KU Leuven

Erik Van der Eycken
Molecular Design and Synthesis

Transition metal catalysis lies at the heart of modern innovative science. To expand this area in organic synthesis, the challenge is to identify novel strategies for the formation of organo-metallic intermediates under mild conditions, and to discover new methods for their subsequent transformation. In this proposal we will focus on the trapping of transient C(sp3)- and C(sp2)-Pd species via C-H activation, or employing oxygen/nitrogen ...

Optimization of cathodes for solid state batteries by insights in the interaction between cathode and solid electrolyte Hasselt University

An HARDY
Laboratory of Inorganic and Physical Chemistry
The need for sustainable mobility leads to a growth of the market of electric cars. At this moment, lithium ion batteries are the most suitable technology due to its high gravimetric and volumetric capacity. In all roadmaps for battery development, solid state batteries are the next step after advanced Li-ion batteries. They offer the potential to significantly increase the energy density, this means a larger driving range for an electric ...

The DUBBLE Beam Lines at the ESRF: Extremely brilliant Xrays for revealing the structure and function of atoms, molecules and materials Hasselt University

Laboratory of Inorganic and Physical Chemistry
Synchrotron X-rays are produced when charged particles circulate in a storage ring close to the speed of light and are much more intense compared to the X-rays used for example in hospitals. By studying the interaction of a synchrotron X-ray beam with matter, the matter structure is revealed down to the atomic and molecular scale. A synchrotron can be imagined as a giant microscope that can look at the inside of non-living and living matter down ...

Understanding the design, synthesis and properties of novel Na ion conducting electrolytes. Hasselt University

An HARDY
Laboratory of Inorganic and Physical Chemistry
Sodium ion batteries are attracting great attention nowadays, e.g. for stationary energy storage. In view of safety, all solid state sodium ion batteries are highly desired. This requires highly conductive sodium ion electrolytes to be designed and synthesized. Building on existing knowledge of Li ion conducting electrolytes, with highly promising properties, the current project proposal prepares the path to sodium ion conducting eutectogels. In ...

Nonlinear optical characterisation of crystal growth KU Leuven

Stijn Van Cleuvenbergen
Chemistry, Kulak Kortrijk Campus, Molecular Imaging and Photonics

Crystallization is of crucial importance in the synthesis, separation and purification of high-end materials in the chemical and pharmaceutical industry. In spite the importance of crystallization, the knowledge about the mechanisms that lead to crystal growth are not well known.

To understand the different stages of crystallization, different techniques were developed based on harmonic scattering. Various properties such as ...