Projects

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A modular and streamlined synthetic platform for diverse polyheterocyclic libraries. KU Leuven

Erik Van der Eycken
Molecular Design and Synthesis

Drug discovery is a lengthy, expensive, difficult, and inefficient process with quite a low rate of new therapeutic discoveries from existing molecules or new molecular entities. These projects generally start with a high-throughput screening campaign of commercially available compound libraries

against the target of interest. However in recent years, it became clear that current combinatorial libraries are not enough. As a mission of ...

Thermally activated delayed fluorescence (TADF) - from rational design to OLED applications. Hasselt University

Wouter MAES
Materials Chemistry, Organic and Bio-polymer Chemistry
- In recent years, a number of organic semiconducting materials have been developed to exploit the new light emission principle of thermally activated delayed fluorescence (TADF). This concept enables to realize unique optical and electronic properties arising from the efficient thermal equilibration of the lowest singlet (S1) and triplet (T1) excited states of organic fluorophores. As a result, TADF-based organic light-emitting diodes (OLEDs) ...

Development of high-performance ultra-low bandgap copolymers for near-infrared photodetectors. Hasselt University

Wouter MAES
Materials Chemistry, Engineering Materials and Applications, Organic and Bio-polymer Chemistry
Due to their application in night and thermal vision systems, infrared image sensors are truly imaginative. To date, they are produced via the so-called hybrid technology, in which both the detector and the electronic readout are prepared separately and then interconnected at the pixel level. Obviously, this is a time-consuming process, resulting in low throughput and thus high cost, limiting widespread use (e.g. smartphones). A monolithic ...

Mass cytometry by time-of-flight: next-generation flow cytometry for multiplexed single cell analysis KU Leuven

Frederik De Smet
Translational Cell & Tissue Research, Translational Research in GastroIntestinal Disorders, Laboratory for Molecular Cancer Biology (VIB-KU Leuven Center for Cancer Biology), Laboratory of Genetics of Autoimmunity (VIB-KU Leuven Center for Brain & Disease Research), Laboratory of Tumor Inflammation and Angiogenesis (VIB-KU Leuven Center for Cancer Biology), Stem Cell and Developmental Biology, Laboratory for Molecular Neurobiomarker Research, Laboratory for Disease Mechanisms in Cancer, Switch Laboratory (VIB-KU Leuven), Laboratory of Experimental Transplantation, Laboratory for Neuroimmunology, Laboratory of Angiogenesis and Vascular Metabolism (VIB-KU Leuven Center for Cancer Biology), Molecular Digestive Oncology, Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven Center for Brain & Disease Research), Clinical and Experimental Endocrinology, Centre for Molecular and Vascular Biology, Therapeutic and Diagnostic Antibodies, Research Group Experimental Neurosurgery and Neuroanatomy, Laboratory of Glia Biology (VIB-KU Leuven Center for Brain & Disease Research)

Describing every single cell in the human body is one of the greatest challenges of our era. Single-cell technologies aim at mapping multiple properties of millions of single cells, both in health and disease. Flow cytometry is still the most important tool for single cell, targeted, protein-based analysis. However, standard fluorescence-based cytometry, which commonly measures <20 markers/cell, hampers major progress to map the enormous ...

Thermally activated delayed fluorescence. Rational design of fluorophores using a joined synthetic and computational chemistry approach Hasselt University

Dirk VANDERZANDE
Materials Chemistry, Organic and Bio-polymer Chemistry
The concept of Thermally Activated Delayed Fluorescence (TADF) enables to realize unique optical and electronic properties arising from the efficient thermal equilibration of the lowest singlet (S1) and triplet (T1) excited states of organic fluorophores. As a result, TADF-based organic light-emitting diodes, oxygen and temperature sensors show significantly upgraded device performances, comparable to those provided by traditional rare metal ...

Solution-processed bulk heterojunction organic cavities for near-infrared photodetection - rational combinations of novel donor and acceptor materials and dedicated solution processing for high performance devices Hasselt University

Wouter MAES
Materials Chemistry, Materials Physics, Organic and Bio-polymer Chemistry
Blending organic electron donors and acceptors yields intermolecular charge transfer (CT) states with additional optical transitions below their optical gaps. In organic photovoltaics, such CT states play a crucial role and they limit the operating voltage. Due to its extremely weak nature, direct intermolecular CT absorption often remains undetected and unused for photocurrent generation. However, the negligible external quantum efficiency ...

Unraveling and stretching the fundamental limits of near-infrared photodetection based on organic semiconductors Hasselt University

Wouter MAES
Materials Chemistry, Materials Physics, Organic and Bio-polymer Chemistry
Due to their application in night and thermal vision systems, infrared image sensors are truly imaginative. To date, the detector and the electronic readout are prepared separately and then interconnected at the pixel level. Obviously, this is a time-consuming process, resulting in low throughput and thus high cost, limiting widespread use. A monolithic approach with direct deposition of the detectors on top of the electronic readout can provide ...

Porphyrinoid materials for near-infrared organic photodetectors Hasselt University

Wouter MAES
Organic and Bio-polymer Chemistry
The eminent threat of terrorism has caused safety and surveillance to become increasingly important aspects in our daily lives. Infrared image sensors can enhance our security by enabling night vision, thermal imaging and chemical sensing applications. To date, the so-called hybrid technology is used for these image sensors, in which both the photodetector (PD) and the electronic readout are prepared separately and then interconnected at the ...

Design and development of biodegradable polymer/ gold nanorod hybrid nano carriers for photothermal cancer therapy : Evaluation by (non-)linear optical methods. Hasselt University

Dirk VANDERZANDE
Materials Physics, Bio-Physics, Organic and Bio-polymer Chemistry
The use of nanoparticles (NPs) in medicine has seen a tremendous rise in interest owing to their vast potential as diagnostic and therapeutic agents. One such instance is the use of nanomaterials for photothermal therapy (PTT) to treat conditions like cancer. PTT is a technique in which localized hyperthermia is induced by converting light energy to heat, to selectively destroy the diseased tissue. This method has been shown to be very ...