Organic synthesis is a powerful method to interrogate biological processes, complementing genetics studies. In this project, innovative synthetic strategies will be developed that can find utility in biology research. As a primary focus, applications in plant biology research will be targeted, as several U+2018small moleculesU+2019 have recently emerged as potent tools to study and control cell biological processes.
Light-Stabilised Dynamic Materials. Ghent University
We very recently discovered a new conceptual approach to design polymer materials that can be reversibly crosslinked upon visible light irradiation, yet importantly be kept stable by light. Here, we are devoted to develop and exploit the potential of this new class of U+2018light-stabilised dynamic materialsU+2019,
which we believe constitutes a key step in the development of next generation light-responsive materials.
Spectator Ligand Effects in Palladium Catalysis (SPEPCAT). Ghent University
The design and understanding of well-defined organometallic architectures are key to modern catalysis. The focus of this project is the need for ever active and longer living complexes leading to the formation of C-C and C-N bonds. We address these challenges by developing a novel paradigm
in well-defined palladium catalysis and investigating the stabilizing/reactivity role of supporting U+201CspectatorU+201D ligands.
Visible-light photoredox catalysis: synthesis of sulfonylated heterocycles via thiosulfonates. University of Antwerp
Development of hydrosilylation catalysts Ghent University
The project describes the synthesis and use of platinum and more Earth-abundant metals (Co and Mn) in the hydrosilylation of alkenes and alkynes. Synthetic approaches will focus on the development of more stable catalysts. The catalysts will be decorated with ligands that will permit their use in processes making us eof nanofiltration for catalyst/substrate/product seperation.
Electrocatalysis Mediated by Organopalladium Complexes Ghent University
The work describes the unique use of electrochemical energy (electrons) as reagents in chemical
reactions. This will be achieved through interactions with metal centers capable of accepting and
donating electrons. This ability to shuffle electrons at the metal center is the foundation of reactivity
of these metals enabling interactions with reagents that lead to bond forming events.
I will focus on a metal that is familiar ...
Application of novel organic reactions for the preparation of new heteroaromatic scaffolds KU Leuven
N-containing heterocycles can be found in several bioactive small molecules, and it is well known that these are very prominent scaffolds in drug discovery. Additionally, the availability of organic reactions for different functionalizations is the key factor that may be limiting the development of new drugs. It is widely accepted that investments in basic chemistry for the development of new synthetic methodologies towards heterocycles are ...
Drug discovery is a lengthy, expensive, difficult, and inefficient process with quite a low rate of new therapeutic discoveries from existing molecules or new molecular entities. These projects generally start with a high-throughput screening campaign of commercially available compound libraries
against the target of interest. However in recent years, it became clear that current combinatorial libraries are not enough. As a mission of ...
Development of polyoxometaltes as artificial enzymes for the selective hydrolysis of membrane- and glyco -proteins for proteomics applications KU Leuven
The total number of different proteins present in Earth organisms is estimated to be up to 10 million. While their identification in terms of primary sequences is expanding at an increasing rate, elucidation of their function and three-dimensional structure is drastically lacking behind. Most of the currently used approaches in proteomics for unraveling the structure and function of proteins require protein hydrolysis into more manageable ...
New avenues for small heterocycles: Expanding the horizon of intra-/inter-molecular trapping of in situ generated transient -alkyl-/vinyl-palladium(II) species. KU Leuven
Transition metal catalysis lies at the heart of modern innovative science. To expand this area in organic synthesis, the challenge is to identify novel strategies for the formation of organo-metallic intermediates under mild conditions, and to discover new methods for their subsequent transformation. In this proposal we will focus on the trapping of transient C(sp3)- and C(sp2)-Pd species via C-H activation, or employing oxygen/nitrogen ...