Projects
Influence of the morphology of core-shell nanoparticles on the mechanism of organic halide reduction University of Antwerp
The development of a selective finger tip biosensor for the on-site detection of cocaïne (APTADRU). University of Antwerp
Development of Cu/Pd-catalyzed Csp3-H and Csp2-H functionalization reaction via a radical mechanism KU Leuven
My work is devoted to the exploration of transition metal-catalyzed direct Csp3-H and Csp2-H functionalization involving radical processes. Several projects about this promising strategy by combined direct C-H functionalization with the high reactivity of radicals will be demonstrated.
Part 1 describes the copper-catalyzed one step direct olefination of benzaldehydes into unsymmetrical 1,3-diarylpropenes, via a novel domino ...
Synthesis of novel compounds with potential antiandrogen activity KU Leuven
Prostate cancer (PCa) is a major public health problem worldwide. It is estimated that it is the second common malignant neoplasm among men representing 13.5% of all the cancers diagnosed in men worldwide. Several therapies of metastatic PCa are based on the inhibition of the androgen receptor (AR) which is the key regulator of the prostate cancer cell growth.
The AR is activated by androgens like testosterone and 5α–dihydrotestosterone ...