Projects
Impact of CO2 and H2 on material behaviour during electrochemical processes Ghent University
Electricity driven production of organics from CO2 may become a key contributor to a circular economy. The materials used are sensitive to CO2 and the intermediate H2. We will investigate impact of these gases, and other constituents of the aqueous media around the materials, on their performance and lifetime particularly when microorganisms are interacting with them.
Application of novel organic reactions for the preparation of new heteroaromatic scaffolds KU Leuven
N-containing heterocycles can be found in several bioactive small molecules, and it is well known that these are very prominent scaffolds in drug discovery. Additionally, the availability of organic reactions for different functionalizations is the key factor that may be limiting the development of new drugs. It is widely accepted that investments in basic chemistry for the development of new synthetic methodologies towards heterocycles are ...
A modular and streamlined synthetic platform for diverse polyheterocyclic libraries. KU Leuven
Drug discovery is a lengthy, expensive, difficult, and inefficient process with quite a low rate of new therapeutic discoveries from existing molecules or new molecular entities. These projects generally start with a high-throughput screening campaign of commercially available compound libraries
against the target of interest. However in recent years, it became clear that current combinatorial libraries are not enough. As a mission of ...
Development of polyoxometaltes as artificial enzymes for the selective hydrolysis of membrane- and glyco -proteins for proteomics applications KU Leuven
The total number of different proteins present in Earth organisms is estimated to be up to 10 million. While their identification in terms of primary sequences is expanding at an increasing rate, elucidation of their function and three-dimensional structure is drastically lacking behind. Most of the currently used approaches in proteomics for unraveling the structure and function of proteins require protein hydrolysis into more manageable ...
New avenues for small heterocycles: Expanding the horizon of intra-/inter-molecular trapping of in situ generated transient -alkyl-/vinyl-palladium(II) species. KU Leuven
Transition metal catalysis lies at the heart of modern innovative science. To expand this area in organic synthesis, the challenge is to identify novel strategies for the formation of organo-metallic intermediates under mild conditions, and to discover new methods for their subsequent transformation. In this proposal we will focus on the trapping of transient C(sp3)- and C(sp2)-Pd species via C-H activation, or employing oxygen/nitrogen ...