Projects

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Electron tomography combined with state-of-the-art electrochemistry to gain better insight into the role of the different components of the active layer in a CO2 electrolyzer. University of Antwerp

Nick Daems
Applied Electrochemistry & Catalysis (ELCAT)
Renewable energy sources can offer a solution for excessive emissions of greenhouse gases and to the expected decrease in availability of fossil fuels in the near future. Both problems would find a common solution if we were able to develop energy-efficient processes to convert (low concentrated) CO2 streams into fuels and useful chemical products, ensuring a positive economic and environmental balance. One possible strategy is to use H2O and ...

Impact of CO2 and H2 on material behaviour during electrochemical processes Ghent University

Kim Verbeken, Korneel Rabaey
Department of Materials, Textiles and Chemical Engineering, Department of Biotechnology

Electricity driven production of organics from CO2 may become a key contributor to a circular economy. The materials used are sensitive to CO2 and the intermediate H2. We will investigate impact of these gases, and other constituents of the aqueous media around the materials, on their performance and lifetime particularly when microorganisms are interacting with them.

Application of novel organic reactions for the preparation of new heteroaromatic scaffolds KU Leuven

Wim Dehaen
Molecular Design and Synthesis

N-containing heterocycles can be found in several bioactive small molecules, and it is well known that these are very prominent scaffolds in drug discovery. Additionally, the availability of organic reactions for different functionalizations is the key factor that may be limiting the development of new drugs. It is widely accepted that investments in basic chemistry for the development of new synthetic methodologies towards heterocycles are ...

A modular and streamlined synthetic platform for diverse polyheterocyclic libraries. KU Leuven

Erik Van der Eycken
Molecular Design and Synthesis

Drug discovery is a lengthy, expensive, difficult, and inefficient process with quite a low rate of new therapeutic discoveries from existing molecules or new molecular entities. These projects generally start with a high-throughput screening campaign of commercially available compound libraries

against the target of interest. However in recent years, it became clear that current combinatorial libraries are not enough. As a mission of ...

Development of polyoxometaltes as artificial enzymes for the selective hydrolysis of membrane- and glyco -proteins for proteomics applications KU Leuven

Tatjana Vogt
Molecular Design and Synthesis

The total number of different proteins present in Earth organisms is estimated to be up to 10 million. While their identification in terms of primary sequences is expanding at an increasing rate, elucidation of their function and three-dimensional structure is drastically lacking behind. Most of the currently used approaches in proteomics for unraveling the structure and function of proteins require protein hydrolysis into more manageable ...

New avenues for small heterocycles: Expanding the horizon of intra-/inter-molecular trapping of in situ generated transient -alkyl-/vinyl-palladium(II) species. KU Leuven

Erik Van der Eycken
Molecular Design and Synthesis

Transition metal catalysis lies at the heart of modern innovative science. To expand this area in organic synthesis, the challenge is to identify novel strategies for the formation of organo-metallic intermediates under mild conditions, and to discover new methods for their subsequent transformation. In this proposal we will focus on the trapping of transient C(sp3)- and C(sp2)-Pd species via C-H activation, or employing oxygen/nitrogen ...

Molecular design of 'Frozen Aptamers': Aptamers with enhanced properties by covalent and non-covalent stabilization using functionalized nucleotides: a combined modelling, NMR and electrochemistry approach. University of Antwerp

Karolien De Wael
AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
The on-site and higly selective detection of cocaine and other important target analytes such as antibiotic residues in waste water remains a challenging area of research. In this project, we wish to better understand and eventually improve analytical detection systems that use short DNA sequences for selective recognition of molecules of interest – called aptamers – followed by the generation of electrical signals upon binding.To achieve this ...

Coupling the inhibition effect of bacteria with amperometric readout for the detection of antibiotics (BACSENS). University of Antwerp

Dieter Vandenheuvel
AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation), Environmental Ecology & Applied Microbiology (ENdEMIC)
Most of the farmers and industries rely on the microbial inhibition tests as a screening tool for a broad range of antibiotics because it is natural, intuitive, and simple enough to be operated by non-specialists outside laboratories. Unfortunately, it suffers from drawbacks such as long analysis time and sensitivity issues. To improve the on-site screening test, we introduce the pioneering idea to couple cost effective and sensitive ...

Fundamental insight into the role of the support and electrocatalyst in CO2 electrolyzers: are carbon-based materials the solution or the problem? University of Antwerp

Tom Breugelmans
Applied Electrochemistry & Catalysis (ELCAT)
Renewable energy sources can offer a solution for excessive emissions of greenhouse gases and to the expected decrease in availability of fossil fuels in the near future. Both problems would find a common solution if we were able to develop energy-efficient processes to convert (low concentrated) CO2 streams into fuels and useful chemical products, ensuring a positive economicand environmental balance. One possible strategy is to use H2O and CO2 ...