Molecular design of 'Frozen Aptamers': Aptamers with enhanced properties by covalent and non-covalent stabilization using functionalized nucleotides: a combined modelling, NMR and electrochemistry approach. University of Antwerp
Antwerp Electrochemical and Analytical Sciences Lab (A-Sense Lab), Ghent University, AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
The on-site and higly selective detection of cocaine and other important target analytes such as antibiotic residues in waste water remains a challenging area of research. In this project, we wish to better understand and eventually improve analytical detection systems that use short DNA sequences for selective recognition of molecules of interest – called aptamers – followed by the generation of electrical signals upon binding.To achieve this ...