Patents

The present invention relates to diagnostic methods to assess the presence of quorum sensing molecules (QSM), preferably peptides (QSPs), that influence muscle wasting in humans. The present invention furthermore relates to the use of the knowledge obtained by the diagnostic method in order to influence muscle wasting diseases in animals and human, by for example providing bacteria that produce beneficial QSMs or non-harmful QSMs, providing antagonists for harmful QSMs and the like.

The present invention is directed to an anti-adsorption solution for the analysis of peptides. Also a process for the preparation of such an anti-adsorption solution and the use of said anti-adsorption solution are described.

Growth performance, health and welfare of domesticated birds such as broilers heavily depends on a well-functioning intestinal tract. Consequently, there is a high need to find biomarkers which are specific for gut damage and which are easily applicable in the field. The present invention discloses a set of 20 specific proteins which can be quantified in fresh fecal droppings and/or intestinal content of said birds and which each specifically correlate with a damaged gut.

The present invention relates to the field of mucin isoforms, more in particular for use in the diagnosis, monitoring, prevention and/or treatment of a disease characterized by barrier dysfunction, such as but not limited to a gastrointestinal disorder (e.g. Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS), cancer, gastro-intestinal infections, obesitas, non-alcoholic fatty liver disease (NAFLD)), neurodegenerative disorders, respiratory infections,... In a specific embodiment, said mucin isoform is selected from the list comprising: MUC1 isoforms and MUC13 isoforms.

The present invention provides an in vitro method for determining the severity and/or prognosis of a respiratory syncytial virus (RSV) infection in a subject, based on the expression of one or more mucin genes in respiratory epithelial cells. The respiratory epithelial cells can be isolated from a biological sample of a subject, or they can be cultured in vitro and exposed to a biological sample of the subject.

A method for determining a minimum inhibitory concentration (MIC) to an antimicrobial drug for a bacteria culture in a container , the method comprising calculating for each well a third derivative of said detected intensity in a first time frame and in a second time frame, said second time frame being subsequent, preferably directly subsequent, to said first time frame; comparing said third derivative of the detected intensity in both said time frames to one or more threshold values; determining a first MIC value based on said comparison of said third derivative in said first time frame to ...

The present invention relates to the identification and use of markers indicative for the response of a subject to immunotherapy as anti-cancer treatment. The markers are particularly useful in predicting response of a subject to immunotherapy with PD-1 or PD-L1 antagonists in the treatment of cancer. PD-1 and PD-L1 antagonists are typically used as immunotherapy in the treatment of several types of cancer, including melanoma, non-small cell lung cancer (NSCLC), and squamous cell carcinoma.

In a first aspect, the present invention relates to a use of a source of formaldehyde for methylating a primary or secondary amine as part of an electrochemical measurement. The source of formaldehyde may in particular be an adduct of formaldehyde.

In a first aspect, the present invention relates to a solid foam, comprising frustules. In a second aspect, the present invention relates to a method for making the solid foam according to the first aspect and its embodiments, comprising: a. forming a gel comprising frustules, b. sintering the frustules into a monolithic structure and c. calcining the gel.

A method for determining a minimum inhibitory concentration (MIC) to an antimicrobial drug for a bacteria culture in a container, the method comprising calculating for each well a third derivative of said detected intensity; comparing said third derivative of the detected intensity to one or more threshold values; determining a MIC value based on said comparison of said third derivative to said one or more threshold values.