Research on four types of functionally active proteins - Copper proteins : hemocyanins (involved in dioxygen binding). - Thiol proteins: metallothioneins (metal detoxication and donation). - Protease inhibitors: alpha -2-macroglobulin homologues. - Regulatory proteins: cytokines (defencesystems against infection). Aim: to determine, after their isolation or possible induction, the composition and the primary to quaternary structure of these ...
The design of new potential drugs is traditionally the domain of the pharmacochemist. In the last decades Quantitative Structure-Activity Relationship (QSAR)-techniques are used more and more to define the 'essential' moieties of a pharmacon. A logical evolution in the search for the relation between the 3D-structure of drugs & their biological activity is the 3D-structure analysis of the biological target molecules and the receptor- ...
General topic : The research aims a better understanding of the interaction of chemical agents with ionising radiation and/or hyperthermia Radiosensibilisation by microtubule inhibitors (Storme) Modulation of accumulation of Vinblastine and other Vincaalkaloids in MO4 cells by means of calcium entry blockers (Storme) Modulation of Cisplatin and Carboplatin toxicity and anti-tumor activity by vasco-active drugs in vivo (W. De Neve)
Biochemistry, Campus Kulak Kortrijk
Research in the Laboratory for Thrombosis Research (Karen Vanhoorelbeke, Simon De Meyer, Hans Deckmyn) at the Kulak campus of KU Leuven focuses on the molecular mechanisms by which the hemostatic proteins von Willebrand factor (VWF) and its cleaving enzyme ADAMTS13 contribute to health and disease. We perform fundamental research to understand the role of VWF and ADAMTS13 in hemostasis, bleeding, ...
Topic A : Diagnostic Microbiology techniques Topic B : Molecular Biology in Infectious Diseases Topic C : Diarrhoeal Diseases Topic D : Sexually Transmitted Diseases Topic E : AIDS