Name "Responsible (Organisation)" "Activity (Organisation)" "Affiliation (Researcher)" "Allergy and Clinical Immunology Research Group" "Dominique Bullens" "1. Allergy Clinical research, cohort based, on drug hypersensitivity Food allergy: clinical driven research into hidden allergens, co-factor enhanced food allergy, rare allergens (allergy to carmine, eatable insect allergens, WDEIA quality of life study etc…) Mastocytosis and hymenoptera venom allergy and treatment: clinical prospective follow-up over 30 years of a large database of patients with hymentoptera venom allergy – coincidence of mastocytosis – role of c-kit determination in peripheral blood in adults Children: (cutaneous vs systemic) mastocytosis: role of c-kit determination in peripheral blood; longitudinal study Role of innate lymphoid cells (ILCs) in chronic intestinal inflammation and intestinal fibrosis (ongoing): intended to broaden ILC research to allergic diseases (food allergy, eosinophilic oesophagitis)2. Tolerance induction Tolerance induction towards allergens: development of both natural (longitudinal studies) and immunotherapy-induced tolerance: study of the role of regulatory T cells and adaptive immunity in environmental and food allergy3. Upper and lower airway hyper-reactivity Study of the impact on epithelial barrier dysfunction on chronic airway inflammation, including interaction with environment, microbiome and therapeutic targets) Study of neuro-immune mechanisms underlying chronic airway inflammation Lower airway inflammation (in close collaboration with lab of pneumology):- in house murine models of allergic asthma- development of new mouse models for non-allergic asthma- role of innate immunity (and ILCs) vs adaptive immunity in those models Translational research in patients with upper and/or lower airway inflammation: immune cells and cytokines recruited/expressed in upper and lower airway tissue: cross-sectional studies and studies after experimental provocation (allergen, exercise, cold air,...) " "Inge Kortekaas Krohn" "Neil Shah" "Inborn Errors of Immunity" "Isabelle Meyts" "Laboratory of Pediatric Immunology has two main research activities: 1) study of allergic diseases with on the one hand upper and lower airway inflammation (in close collaboration with labs of clinical immunology and pneumology) for which we study in house running murine models of allergic asthma and develop of new mouse models for non-allergic asthma, as well as translational research in patients with upper and/or lower airway inflammation with cross-sectional studies and studies after experimental provocation  (allergen, exercise, cold air, ..) and on the other hand tolerance induction towards allergens, for which we focus on natural (longitudinal studies) and induced (immunotherapy) tolerance and (cutaneous vs systemic) mastocytosis in children; 2) the study of primary immune deficiencies (PID):  for which we perform Exome and genome sequencing for inborn errors of immunity, such as Hyper-IgE and IPEX syndrome: novel mutation analysis, Stat 1 gain of function mutations: clinical phenotype and molecular analysis  and the role of hematopoietic stem cell transplantation for PID." "Mieke Gouwy" "Molecular Immunology (Rega Institute)" "Sonja Bobic" "Kristine Desager" "Paul Van Cauwenberge" "Sven Seys" "Janne Goossens" "Environment and Health"