Researcher
Zeger Debyser
- Disciplines:Laboratory medicine, Microbiology, Systems biology, Biomaterials engineering, Biological system engineering, Biomechanical engineering, Other (bio)medical engineering, Environmental engineering and biotechnology, Industrial biotechnology, Other biotechnology, bio-engineering and biosystem engineering
Affiliations
- Molecular Virology and Gene Therapy (Division)
Responsible
From1 Jan 2012 → Today - Molecular Virology and Gene Therapy (Division)
Member
From1 Jan 2013 → Today - Faculty of Medicine, Kulak Kortrijk Campus (Faculty)
Member
From1 Oct 2003 → 29 Feb 2008 - Faculty of Medicine (Faculty)
Member
From1 Oct 1999 → 30 Sep 2003
Projects
1 - 10 of 77
- Bottom-up manufacturing of artificial anti-tumor T cellsFrom1 Feb 2024 → TodayFunding: HORIZON.3.1 - European Innovation Council (EIC)
- DEVELOPMENT OF LINE-1 INHIBITORSFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Design of targeted degraders of LEDGF/p75 with applications as anticancer agentsFrom25 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- HIV Latency and the epigenetic landscape: studying individual patients for developing HIV cure strategiesFrom1 Mar 2023 → TodayFunding: Geopolitical funding in general (R&D collaboration with Central and Eastern Europe
- Towards a functional cure strategy of HIV infection: Single virus imaging to study the impact of HIV nuclear import and integration on transcription and latencyFrom1 Sep 2022 → TodayFunding: FWO Strategic Basic Research Grant
- INNOVATIVE THERAPIES FOR LINE-1 DISEASEFrom1 May 2022 → TodayFunding: BOF - various
- Single virus live imaging of HIV nuclear import and integrationFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Targeting LEDGF/p75 for Mixed Lineage Leukemia and chemoresistant malignanciesFrom16 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Role of the epigenetic reader LEDGF/p75 in health and diseaseFrom1 Oct 2021 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- Role of the interaction between LEDGF and MeCP2 in LINE-1 retrotransposition in the brainFrom1 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
271 - 280 of 305
- Structural modification of diketo acid portion in 1h-benzylindole derivatives hiv-1 integrase inhibitors(2009)
Authors: Zeger Debyser
Pages: 947 - 959 - Integrase as a Novel Target for the Inhibition of Human Immunodeficiency Virus Type 1 Infection: Current Status and Future Perspectives(2009)
Authors: Frauke Christ, Zeger Debyser, Arnout Voet
Pages: 71 - +Number of pages: 33 - In vivo bioluminescence imaging in an experimental mouse model for dendritic cell based immunotherapy against malignant glioma(2009)
Authors: Wim Maes, Christophe Deroose, Veerle Reumers, Olga Krylychkina, Rik Gijsbers, Veerle Baekelandt, Jan Ceuppens, Zeger Debyser, Stefaan Van Gool
Pages: 127 - 139 - LEDGF/p75 and transportin-SR2 are cellular cofactors of HIV integrase and novel targets for antiviral therapy(2009)
Authors: Wannes Thys, Katrien Busschots, Melissa McNeely, Arnout Voet, Frauke Christ, Zeger Debyser
Pages: 171 - 188 - In search of small molecules blocking interactions between HIV proteins and intracellular cofactors(2009)
Authors: Jan De Rijck, Frauke Christ, Zeger Debyser
Pages: 21 - 31 - Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions(2009)
Authors: Frauke Christ, Myriam Witvrouw, Zeger Debyser
Pages: 569 - 573 - Novel Approach to Intermediate Scale AAV Vector Manufacturing and Separation of Distinct AAV Entities on Iodixanol Gradients(2009)
Authors: Martin Lock, Jaan Toelen, Luk H Vandenberghe, Maruicio Alvira, Arabinda Samanta, Zeger Debyser, James M Wilson
Pages: S272 - S273 - EVALUATION OF DIFFERENT SCREENING MODELS FOR OPTIMAL PULMONARY TRANSDUCTION WITH LENTIVIRAL VECTORS(2008)
Authors: Marianne Carlon, Jaan Toelen, Steffi Mayer, Rik Gijsbers, Lourenco Sbragia, Jan Deprest, Zeger Debyser
Pages: S187 - S187 - EFFECTS OF TRACHEAL OCCLUSION AND ALBUMIN ON PROLIFERATION IN FETAL RATS WITH NITROFEN INDUCED CONGENITAL DIAPHRAGMATIC HERNIA - A PLACEBO CONTROLLED MOLECULAR STUDY(2008)
Authors: Philipp Klaritsch, Steffi Mayer, Lourenco Sbragia, Jaan Toelen, Zeger Debyser, Martin Haeusler, Xenia Roubliova, Jan Deprest
Pages: S79 - S79 - Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain(2008)
Authors: Myriam Witvrouw, Frauke Christ, Zeger Debyser
Pages: 7717 - 7730
Patents
1 - 9 of 9
- Functional cure of retroviral infection (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno[2,3-b]pyridine derivatives as viral replication inhibitors (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors (Inventor)
- ;Antiviral compounds (Inventor)
- THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS (Inventor)
- VIRAL REPLICATION INHIBITORS (Inventor)
- NOVEL ANTIVIRAL COMPOUNDS (Inventor)