Researcher
Zeger Debyser
- Disciplines:Laboratory medicine, Microbiology, Systems biology, Biomaterials engineering, Biological system engineering, Biomechanical engineering, Other (bio)medical engineering, Environmental engineering and biotechnology, Industrial biotechnology, Other biotechnology, bio-engineering and biosystem engineering
Affiliations
- Molecular Virology and Gene Therapy (Division)
Responsible
From1 Jan 2012 → Today - Molecular Virology and Gene Therapy (Division)
Member
From1 Jan 2013 → Today - Faculty of Medicine, Kulak Kortrijk Campus (Faculty)
Member
From1 Oct 2003 → 29 Feb 2008 - Faculty of Medicine (Faculty)
Member
From1 Oct 1999 → 30 Sep 2003
Projects
1 - 10 of 77
- Bottom-up manufacturing of artificial anti-tumor T cellsFrom1 Feb 2024 → TodayFunding: HORIZON.3.1 - European Innovation Council (EIC)
- DEVELOPMENT OF LINE-1 INHIBITORSFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Design of targeted degraders of LEDGF/p75 with applications as anticancer agentsFrom25 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- HIV Latency and the epigenetic landscape: studying individual patients for developing HIV cure strategiesFrom1 Mar 2023 → TodayFunding: Geopolitical funding in general (R&D collaboration with Central and Eastern Europe
- Towards a functional cure strategy of HIV infection: Single virus imaging to study the impact of HIV nuclear import and integration on transcription and latencyFrom1 Sep 2022 → TodayFunding: FWO Strategic Basic Research Grant
- INNOVATIVE THERAPIES FOR LINE-1 DISEASEFrom1 May 2022 → TodayFunding: BOF - various
- Single virus live imaging of HIV nuclear import and integrationFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Targeting LEDGF/p75 for Mixed Lineage Leukemia and chemoresistant malignanciesFrom16 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Role of the epigenetic reader LEDGF/p75 in health and diseaseFrom1 Oct 2021 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- Role of the interaction between LEDGF and MeCP2 in LINE-1 retrotransposition in the brainFrom1 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
251 - 260 of 305
- LEDGF/p75 is critical but not essential for multiple-round HIV 1 replication.(2010)
Authors: Rik Schrijvers, J De Rijck, Rik Gijsbers, K Ronen, FD Bushman, Zeger Debyser
Pages: O10 - O10 - Lentiviral integration and the role of the cellular cofactors LEDGF/p75 and transportin-SR2(2010)
Authors: Bart van Heertum, Jan De Rijck, Zeger Debyser
Pages: 375 - 406 - Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints(2009)
Authors: Zeger Debyser
Pages: 1416 - 1428 - State-of-the-art lentiviral vectors for research use: risk assessment and biosafety recommendations(2009)
Authors: Rik Gijsbers, Jaan Toelen, Zeger Debyser
Pages: 459 - 474 - Combined non-invasive bioluminiscence and magnetic resonance imaging improves detection after pulmonary gene transfer in a fetal mouse model(2009)
Authors: Marianne M.S. Carlon, Jaan Toelen, Uwe Himmelreich, Zeger Debyser, Jan Deprest
Pages: S261 - S261 - Fetal tracheal injection technique to target the fetal mouse lung(2009)
Authors: Jaan Toelen, Marianne M.S. Carlon, Steffi Mayer, Lourenco Sbragia, Zeger Debyser, Jan Deprest
Pages: S261 - S261 - Novel and scalable approach to research grade AAV vector manufacturing and separation of distinct AAV serotypes(2009)
Authors: Jaan Toelen, Martin Lock, Luk Vandenberghe, Marianne Carlon, James Wilson, Zeger Debyser
Pages: 1435 - 1435 - Comparison of different rAAV serotypes for transduction of dopaminergic neurons in rat substantia nigra(2009)
Authors: Anke Van der Perren, Jaan Toelen, Luk Vandenberghe, James Wilson, Zeger Debyser, Veerle Baekelandt
Pages: 1449 - 1449 - Evaluation of a novel delivery strategy for pulmonary gene transfer in a fetal mouse model using AAV6.2(2009)
Authors: Marianne Carlon, Jaan Toelen, Luk Vandenberghe, Jan Deprest, James Wilson, Zeger Debyser
Pages: 1477 - 1477 - In search of second generation HIV integrase inhibitors; targeting integration beyond strand transfer(2009)
Authors: Arnout Voet, Marc De Maeyer, Zeger Debyser, Frauke Christ
Pages: 1259 - 1274
Patents
1 - 9 of 9
- Functional cure of retroviral infection (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno[2,3-b]pyridine derivatives as viral replication inhibitors (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors (Inventor)
- ;Antiviral compounds (Inventor)
- THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS (Inventor)
- NOVEL ANTIVIRAL COMPOUNDS (Inventor)
- VIRAL REPLICATION INHIBITORS (Inventor)