Researcher
Xavier Saelens
- Keywords (Ghent University):antiviral immunity, virology, vaccines
- Disciplines (Flanders Institute for Biotechnology):Analytical biochemistry, Cell death and senescence, Analysis of next-generation sequence data, General diagnostics
- Disciplines (Ghent University):Applied immunology, Drug discovery and development not elsewhere classified, Clinical trials, Biopharmaceuticals, In vitro testing, Non-clinical studies, Animal immunology, Transcription and translation, Vaccines, Molecular and cell biology not elsewhere classified, Virology
- See also: Xavier Saelens (Flanders Institute for Biotechnology)
Affiliations
- Department of Biochemistry and microbiology (Department)
Member
From1 Oct 2018 → Today - Saelens Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Biomedical molecular biology (Department)
Member
From1 Jan 1996 → 30 Sep 2018 - Department of Plant Biotechnology and Bioinformatics (Department)
Member
From1 Jan 1993 → 31 Dec 1995
Projects
1 - 10 of 21
- Development of intrabody-expressing influenza virus vectors to discover new pro- and antiviral host factorsFrom1 Nov 2023 → TodayFunding: FWO Strategic Basic Research Grant
- New antivirals against human parainfluenza virusFrom1 Apr 2023 → TodayFunding: IOF - technology validation in lab
- Flow imaging microscope for advanced analysis of biopharmaceuticals and biological samplesFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Prepared for SARS-CoV-3: advancing our understanding of SARS coronavirus antigenic and pathogenic evolutionFrom1 Jan 2022 → TodayFunding: FWO EOS
- A nanobody-based anti-inflammatory treatment against Pseudomonas aeruginosa-induced inflammation in chronic lung diseases.From1 Nov 2021 → TodayFunding: FWO Strategic Basic Research Grant
- A nanobody-based anti-inflammatory treatment against Pseudomonas aeruginosa-induced inflammation in chronic lung diseasesFrom1 Oct 2021 → 31 Oct 2021Funding: BOF - doctoral mandates
- A nanobody-based anti-inflammatory treatment against pathogen-induced chronic lung inflammationFrom1 Oct 2021 → TodayFunding: BOF - projects
- Designed, broadly protective antibodies directed against influenza B.From1 Nov 2020 → TodayFunding: FWO Strategic Basic Research Grant
- mRNA Lipid nanoparticles co-loaded with alpha-Galactosylceramide as a universal influenza vaccine platformFrom1 Oct 2020 → 30 Sep 2022Funding: BOF - postdoctoral mandates
- Prophylaxis of at risks persons with an ultrapotent SARS-CoV-2-neutralizing antibodyFrom22 May 2020 → 31 May 2021Funding: FWO Special Call for Covid-19 research projects
Publications
11 - 20 of 39
- Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells(2019)
Authors: Lien Van Hoecke, Laurens Raes, Stephan Stremersch, Toon Brans, Juan Fraire, Ria Roelandt, Wim Declercq, Peter Vandenabeele, Koen Raemdonck, Kevin Braeckmans, et al.
- Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice(2019)
Authors: Patrick Tjok Joe, Ioanna Christopoulou, Lien Van Hoecke, Bert Schepens, Tine Ysenbaert, Carlo Heirman, Kris Thielemans, Xavier Saelens, Joeri Aerts
- Mx1 in hematopoietic cells protects against Thogoto virus infection(2019)
Authors: Jan Spitaels, Lien Van Hoecke, Kenny Roose, Georg Kochs, Xavier Saelens
- Super-resolution microscopy reveals significant impact of M2e-specific monoclonal antibodies on influenza A virus filament formation at the host cell surface(2019)
Authors: Annasaheb Kolpe, Maria Arista-Romero, Bert Schepens, Silvia Pujals, Xavier Saelens, Lorenzo Albertazzi
- Respiratory syncytial virus nonstructural proteins 1 and 2 : exceptional disrupters of innate immune responses(2019)
Authors: Koen Sedeyn, Bert Schepens, Xavier Saelens
- Selective engagement of FcγRIV by a M2e-specific single domain antibody construct protects against influenza A virus infection(2019)
Authors: Dorien De Vlieger, Katja Hoffmann, Inge Van Molle, Wim Nerinckx, Lien Van Hoecke, Marlies Ballegeer, Sarah Creytens, Han Remaut, Hartmut Hengel, Bert Schepens, et al.
- New antibody-based prevention and treatment options for influenza(2019)
Authors: Koen Sedeyn, Xavier Saelens
- Antibodies directed toward neuraminidase N1 control disease in a mouse model of influenza(2018)
Authors: Emma Job, Michael Schotsaert, Lorena Ibanez, Anouk Smet, Tine Ysenbaert, Kenny Roose, M. Dai, C. A. M. de Haan, H. Kleanthous, T. U. Vogel, et al.
- One against all : a broadly influenza neutralizing man-made monoclonal antibody passes phase I(2016)
Authors: Xavier Saelens
Pages: 16 - 17 - Influenza and memory T cells : how to awake the force(2016)
Authors: Jan Spitaels, Kenny Roose, Xavier Saelens
Patents
1 - 9 of 9
- CORONA VIRUS BINDERS (Inventor)
- METHODS OF GENERATING BROADLY PROTECTIVE VACCINE COMPOSITIONS COMPRISING NEURAMINIDASE (Inventor)
- MIXED-LINEAGE KINASE DOMAIN-LIKE PROTEIN IN IMMUNOTHERAPEUTIC CANCER CONTROL (Inventor)
- Anti-influenza antibody (Inventor)
- SINGLE DOMAIN ANTIBODY AGAINST RSV F PROTEIN (Inventor)
- METHODS OF GENERATING BROADLY PROTECTIVE VACCINE COMPOSITIONS COMPRISING NEURAMINIDASE (Inventor)
- MIXED-LINEAGE KINASE DOMAIN-LIKE PROTEIN IN IMMUNOTHERAPEUTIC CANCER CONTROL (Inventor)
- RESPIRATORY SYNCYTICAL VIRUS VACCINE (Inventor)
- Anti-influenza antibody (Inventor)