Researcher
Wim Van Hul
- Research Expertise:Genetic analyses of obesity and comorbidities and skeletal dysplasias
- Keywords:SKELETAL DYSPLASIAS, OBESITY, PAGET DISEASE, GENETIC DISEASE, Biomedical sciences (incl. biochemistry)
- Disciplines:Endocrinology and metabolic diseases, Molecular and cell biology, Metabolic diseases, Genetics
- Research techniques:DNA-sequencing, Next generation sequencing, cloning, expression studies, cell cultures, animal models (mouse and zebrafish)
- Users of research expertise:teams with complementary expertise and interest
Affiliations
- Medical Genetics (MEDGEN) (Research group)
Member
From1 Oct 2022 → Today - Medical genetics of obesity and skeletal disorders (MGENOS) (Research group)
Responsible
From1 Oct 2003 → 30 Sep 2022
Projects
11 - 20 of 27
- Evaluation of the role of LRP4 in the regulation of Wnt/Bcatenin dependent Wnt signalling and bone formation.From1 Oct 2013 → 30 Sep 2016Funding: FWO fellowships
- Genetic analysis of five candidate genes in the pathogenesis of obesity.From1 Jan 2013 → 31 Dec 2016Funding: IWT personal funding - strategic basic research grants
- Next generation sequencing technology opening new frontiers in biological and medical research.From28 Jun 2012 → 31 Dec 2017Funding: ITG (Institute for Tropical Medicine), Hercules - Small and Medium size research infrastructure, Nonprofit institution or equivalents, FWO Medium Size Research Infrastructure
- Belgian medical genomics initiative (BeMGI).From1 Apr 2012 → 31 Dec 2017Funding: IUAP-VII
- Identification and characterization of the gene underlying hyperostosis cranialis interna.From1 Jan 2012 → 31 Dec 2015Funding: FWO research project (including WEAVE projects)
- Genetic and functional study of LRP4 and the R-spondins in bone formation.From1 Jan 2012 → 31 Dec 2015Funding: IWT personal funding - strategic basic research grants
- Genetic and functional study of the effect of sclerostin-binding proteins on bone anabolism.From1 Oct 2011 → 31 Dec 2011Funding: BOF - Other initiatives
- Genetic analysis of the role of sFRP1 and 4 in the bone homeostasis.From1 Jan 2011 → 31 Dec 2012Funding: IWT personal funding - strategic basic research grants
- Positional cloning of two genes responsible for an abnormal bone density.From1 Jan 2011 → 31 Dec 2012Funding: IWT personal funding - strategic basic research grants
- Genetic and functional analysis of two genes underlying an osteopetrotic rat model (incisors absent and osteopetrotic).From1 Jan 2010 → 31 Dec 2013Funding: FWO research project (including WEAVE projects)
Publications
1 - 10 of 177
- Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in metabolic dysfunction associated Steatotic liver disease (MASLD)(2024)
Authors: Claudia Theys, Tineke Vanderhaeghen, Evelien Van Dijck, Cédric Peleman, Anne Scheepers, Joe Ibrahim, Ligia Monica Mateiu, Steven Timmermans, Tom Vanden Berghe, Sven Francque, et al.
Pages: 1 - 19 - A mosaic variant in CTNNB1/β-catenin as a novel cause for osteopathia striata with cranial sclerosis(2024)
Authors: Yentl Huybrechts, Natasha M. Appelman-Dijkstra, Ellen Steenackers, Wouter Van Beylen, Geert Mortier, Gretl Hendrickx, Wim Van Hul
Pages: 1 - 8 - An additional Lrp4 high bone mass mutation mitigates the sost-knockout phenotype in mice by increasing bone remodeling(2024)
Authors: Gretl Hendrickx, Eveline Boudin, Ligia Monica Mateiu, Timur A. Yorgan, Ellen Steenackers, Michaela Kneissel, Ina Kramer, Geert Mortier, Thorsten Schinke, Wim Van Hul
Pages: 171 - 181 - A recessive form of craniodiaphyseal dysplasia caused by a homozygous missense variant in SP7/Osterix(2023)
Authors: Gretl Hendrickx, Eveline Boudin, Ellen Steenackers, Corinne Collet, Geert Mortier, David Genevi, Wim Van Hul
Pages: 1 - 9 - Heterozygous pathogenic variants involving CBFB cause a new skeletal disorder resembling cleidocranial dysplasia(2023)
Authors: Tessi Beyltjens, Eveline Boudin, Nicole Revencu, Nele Boeckx, Miriam Bertrand, Leon Schuetz, Tobias B. Haack, Axel Weber, Eleni Biliouri, Mateja Vinksel, et al.
Pages: 498 - 504 - High bone mass disorders(2023)
Authors: Dylan J.M. Bergen, Antonio Maurizi, Melissa M. Formosa, Georgina L.K. McDonald, Ahmed El-Gazzar, Neelam Hassan, Maria-Luisa Brandi, Jose A. Riancho, Fernando Rivadeneira, Evangelia Ntzani, et al.
Pages: 229 - 247 - Identification of a novel nonsense variant in the DLL3 gene underlying spondylocostal dysostosis in a consanguineous Pakistani family(2023)
Authors: Feroz Khan, Abida Arshad, Asmat Ullah, Ellen Steenackers, Geert Mortier, Wasim Ahmad, Muhammad Arshad, Sarmir Khan, Amir Hayat, Ikram Khan, et al.
Pages: 191 - 200 - Unraveling the genetic landscape of high bone mass disorders and Paget’s disease of bone: From variant identification and validation to zebrafish modeling(2023)
Authors: Yentl Huybrechts, Wim Van Hul
Number of pages: 194 - Osteocytic sclerostin expression as an indicator of altered bone turnover(2023)
Authors: Yentl Huybrechts, Pieter Evenepoel, Mathias Haarhaus, Etienne Cavalier, Geert Dams, Wim Van Hul, Patrick D'Haese, Anja Verhulst
Pages: 1 - 15 - Editorial(2022)
Authors: Teun J. de Vries, Wim Van Hul, E. Marelise Eekhoff
Pages: 1 - 3