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Researcher
Wim Annaert
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Intracellular compartments and transport
- See also: Annaert Wim (Flanders Institute for Biotechnology)
Affiliations
- Laboratory of Membrane Trafficking (VIB-KU Leuven) (Lab)
Responsible
From1 Jan 2006 → Today - Laboratory of Membrane Trafficking (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → Today - Annaert Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 31 Dec 2016
Projects
1 - 10 of 45
- Impact of neuronal lysosomal dysfunction on RNA transport and local translation in Alzheimer’s diseaseFrom15 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Unraveling a novel role for PSEN2/?-secretase in late endosome/lysosome-endoplasmic reticulum contact sites: impact on Alzheimer’s disease pathogenesisFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- Unraveling the unprecedented roles for Presenilin/?-secretase in inter-organellar membrane contact sites and how this modulates cellular calcium homeostasisFrom1 Oct 2022 → TodayFunding: FWO senior postdoctoral fellowship
- 3D SUper-Resolution to cryo-Electron MIcroscopy to study nanoscale subcellular dynamics and structure that alter in Neurodegenerative Diseases - 3SURE MINDFrom1 May 2022 → TodayFunding: FWO Large scale research infrastructure
- The impact of lysosomal Phospholipase D3 deficiency on activated response microglia regulationFrom1 Oct 2021 → TodayFunding: FWO fellowships
- Inter-organelle communication through membrane contact sites in oncology and neurodegenerative diseases (InterAction)From1 Oct 2021 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- The role of Rer1 in ER-related homeostatic mechanismsFrom1 Jan 2021 → 31 Dec 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- Dynamic super-resolution microscopy: a gateway for cell biologists to understand molecular machines at work in living cells during homeostasis & diseaseFrom1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- The lysosomal exonuclease PLD3 as an endolysosomal flux regulator: impact on neuronal homeostasis and relevance in neurodegeneration.From1 Oct 2020 → 30 Sep 2023Funding: FWO junior postdoctoral fellowship
- Lysosomal Homeostasis in Alzheimer's diseaseFrom25 Sep 2020 → 11 Dec 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
71 - 80 of 87
- Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis(2010)
Authors: Philip Gordts, Pascale Zimmermann, Wim Annaert, Anton Roebroek
Pages: 135 - 145 - Amyloid precursor family proteins are expressed by thymic and lymph node stromal cells but are not required for lymphocyte development(2009)
Authors: Wim Annaert
Pages: 1163 - 1174 - Golgi function and dysfunction in the first COG4-deficient CDG type II patient(2009)
Authors: Ellen Reynders, François Foulquier, Wim Annaert, Gert Matthijs
Pages: 3244 - 3256 - Regulated intramembrane proteolysis--a story about sheddases and I-CliPs(2009)
Authors: Wim Annaert
Pages: 125 - Trafficking, a key component in regulated intramembrane proteolysis(2009)
Authors: Wim Annaert
Pages: 183 - 190 - Chemical and biological characterization of thiol SAMs for neuronal cell attachment(2009)
Authors: Karolien Jans, Wim Annaert, Guido Maes, Yves Engelborghs, Gustaaf Borghs, Carmen Bartic
Pages: 4564 - 4570 - Regulation of gamma-secretase complex assembly in the early secretory pathway -from Alzheimer's disease to monosomy 1p36-(2009)
Authors: Dragana Spasic, Wim Annaert
- ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins is processed by ADAMs9, -15, and the gamma-secretase(2009)
Authors: Thomas Tousseyn, Amantha Thathiah, Ellen Jorissen, Wim Annaert, Bart De Strooper
Pages: 11738 - 11747 - Cerebrocostomandibular-like syndrome and a mutation in the conserved oligomeric Golgi complex, subunit 1(2009)
Authors: François Foulquier, Boyan Dimitrov, Ellen Reynders, Rita Lombaerts, Wim Annaert, Gert Matthijs
Pages: 517 - 524 - Building β-secretase -: the bits and pieces(2008)
Authors: Dragana Spasic, Wim Annaert
Pages: 413 - 420
Patents
1 - 9 of 9
- Gamma-secretase inhibitor screening assay (Inventor)
- Screening methods for compounds modulating polyamine transport (Inventor)
- Gamma-secretase inhibitor screening assay (Inventor)
- Method and apparatus for the imaging of a labeled biological sample (Inventor)
- Bace1 inhibitory antibodies (Inventor)
- Plasma membrane isolation (Inventor)
- BACE1 inhibitory antibodies (Inventor)
- Plasma membrane isolation (Inventor)
- SCREENING METHODS FOR COMPOUNDS THAT MODULATE ARF-6 MEDIATED ENDOSOMAL REDISTRIBUTION (Inventor)