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Researcher
Veerle Janssens
- Disciplines:Proteins, Cell division, Cell signalling, Posttranslational modifications, Cancer biology, Cancer therapy, Developmental biology, Genetics
Affiliations
- Laboratory of Protein Phosphorylation and Proteomics (Division)
Responsible
From1 Oct 2021 → Today - Laboratory of Protein Phosphorylation and Proteomics (Division)
Member
From1 Oct 2007 → Today
Projects
11 - 20 of 23
- Role of c-Myc-PP2A negative feedback control in liver biology: new avenues for improved treatment of hepatocellular carcinoma.From5 Feb 2018 → 10 Nov 2023Funding: FWO Strategic Basic Research Grant
- Targeting radiotherapy resistance in Head and Neck Cancers: the potential biomarker role of TIPRL1 and CIP2A, two cellular inhibitors of Protein Phosphatase 2AFrom1 Jan 2018 → 22 Nov 2023Funding: BOF - doctoral mandates
- LGR6 in Chronic Lung DiseasesFrom1 Dec 2017 → 18 Oct 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Targeting radiation resistance of Head and Neck Squamous Cell CarcinomaFrom1 Oct 2017 → 30 Sep 2021Funding: Fund Recuperation Fiscal Exemption, BOF - Concerted Research Project from 1994
- The biological role and therapeutic biomarker potential of PPP2R4 in lung cancer: a pre-clinical proof-of-concept study in human and mouse NSCLC modelsFrom1 Jan 2017 → 31 Dec 2020Funding: Foundations, funds and other with scientific goal
- Development and characterization of disease models of B56deltopathy, a new syndromic variant of severe intellectual disability: new tools for therapeutic intervention.From22 Dec 2016 → 2 Jul 2021Funding: FWO Strategic Basic Research Grant
- Role of cMyc-PP2A negative feedback control in hepatocyte growth, liver regeneration and hepatocellular carcinoma developmentFrom1 Jan 2016 → 31 Dec 2019Funding: FWO research project (including WEAVE projects)
- The role of the Protein Phosphatase 2A Activator PTPA in KRAS-mutant non-small-cell lung cancer development and treatment resistanceFrom1 Feb 2015 → 10 Nov 2021Funding: BOF - Doctoral projects
- PP2A as a component of negative feedback loops: role in cancer developmement progression.From1 Oct 2013 → 30 Sep 2017Funding: BOF - Concerted Research Project from 1994
- Novel insights in the pharmacological inhibition and isoform-specific regulation of protein kinase D2.From1 Mar 2013 → 5 Jul 2017Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 83
- Function of PP2A methylesterase-1 PME-1 in the stress response: implications for glioblastoma treatment(2023)
Authors: Liesbeth Guffens, Veerle Janssens, Rita Derua
- Targeting radiotherapy resistance in Head and Neck Cancers: the potential biomarker role of TIPRL1 and CIP2A, two cellular inhibitors of Protein Phosphatase 2A(2023)
Authors: Célie Cokelaere, Veerle Janssens, Rita Derua, Sandra Nuyts
- TIPRL1 and its ATM‑dependent phosphorylation promote radiotherapy resistance in head and neck cancer(2023)
Authors: Célie Cokelaere, Rüveyda Dok, Emanuela Elsa Cortesi, Anna Sablina, Sandra Nuyts, Rita Derua, Veerle Janssens
- PME-1-regulated neural cell death: new therapeutic opportunities?(2023)
Authors: Liesbeth Guffens, Rita Derua, Veerle Janssens
Pages: 11694 - 11696 - The tumor suppressive role of Protein Phosphatase 2A B56δ subunit in primary liver cancer(2023)
Authors: Judit Domènech Omella, Veerle Janssens
- Editorial: Deciphering the etiology of rare genetic disorders associated with protein phosphatases(2023)
Authors: Veerle Janssens
- A Novel Mouse Model of Combined Hepatocellular-Cholangiocarcinoma Induced by Diethylnitrosamine and Loss of Ppp2r5d(2023)
Authors: Judit Domènech Omella, Emanuela Elsa Cortesi, Iris Verbinnen, Michiel Remmerie, Tania Roskams, Veerle Janssens
- PME-1 sensitizes glioblastoma cells to oxidative stress-induced cell death by attenuating PP2A-B55α-mediated inactivation of MAPKAPK2-RIPK1 signaling(2023)
Authors: Liesbeth Guffens, Rita Derua, Veerle Janssens
- Human pancreatic cancer patients with Epithelial-to-Mesenchymal Transition and an aggressive phenotype show a disturbed balance in Protein Phosphatase Type 2A expression and functionality.(2023)
Authors: Jos van Pelt, Rita Derua, Liesbeth Guffens, Veerle Janssens, Chris Verslype
- C-glycosides analogues of the okadaic acid central fragment exert neuroprotection via restoration of PP2A-phosphatase activity: A rational design of potential drugs for Alzheimer?s disease targeting tauopathies(2023)
Authors: Veerle Janssens
Patents
1 - 2 of 2
- Pro-apoptotic set and pp2a peptides (Inventor)
- Pro-apoptotic set and pp2a peptides (Inventor)