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Researcher
Tom Van Loy
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Sep 2015 → Today - Animal Physiology and Neurobiology (Division)
Member
From1 Oct 2001 → 30 Sep 2009
Projects
1 - 3 of 3
- Development and evaluation of new classes of CXCR2 antagonists with applications in inflammation and infectionFrom3 Sep 2019 → 3 Sep 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Establishment of in vitro assays for the discovery of GPCR small molecule ligandsFrom30 May 2018 → 30 May 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Identification of novel chemokine receptor inhibitors for anti-cancer therapyFrom1 Oct 2017 → 30 Sep 2019Funding: Fund Recuperation Fiscal Exemption, BOF - Concerted Research Project from 1994
Publications
1 - 10 of 39
- trans-IV restriction: a new configuration for metal bis-cyclam complexes as potent CXCR4 inhibitors.(2024)
Authors: Tom Van Loy, Dominique Schols
Pages: 5616 - 5623 - Systematic Assessment of Human CCR7 Signalling Using NanoBRET Biosensors Points towards the Importance of the Cellular Context(2024)
Authors: Katrijn Boon, Dominique Schols, Tom Van Loy
- Systematic assessment of chemokine ligand bias at the human chemokine receptor CXCR2 indicates G protein bias over β-arrestin recruitment and receptor internalization(2024)
Authors: Katrijn Boon, Dominique Schols, Tom Van Loy
- Development of a cellular model to study CCR8 signaling in tumor-infiltrating regulatory T cells(2024)
Authors: Libao Liu, Susan Schlenner, Steven De Jonghe, Dominique Schols, Tom Van Loy
- Synthesis and structure-activity relationship study of phenoxybenzylpiperazine analogues as CCR8 agonists(2023)
Authors: Yenthel Verhaegen, Stijn Anthonissen, Tom Van Loy, Dominique Schols, Wim Dehaen, Steven De Jonghe
- REGA-SIGN: Development of a Novel Set of NanoBRET-Based G Protein Biosensors(2023)
Authors: Katrijn Boon, Dominique Schols, Tom Van Loy
- Optimization of triazolo[4,5-d]pyrimidines towards human CC chemokine receptor 7 (CCR7) antagonists(2023)
Authors: Tom Van Loy, Dominique Schols, Wim Dehaen, Steven De Jonghe
- Exploration of Pyrido[3,4-d]pyrimidines as Antagonists of the Human Chemokine Receptor CXCR2(2023)
Authors: Katrijn Boon, Tom Van Loy, Dominique Schols, Wim Dehaen, Steven De Jonghe
- Cellular Electrical Impedance as a Method to Decipher CCR7 Signalling and Biased Agonism(2022)
Authors: Katrijn Boon, Dominique Schols, Tom Van Loy
- Stimulation of the atypical chemokine receptor 3 (ACKR3) by a small-molecule agonist attenuates fibrosis in a preclinical liver but not lung injury model(2022)
Authors: Tom Van Loy, Steven De Jonghe, Wouter Dheedene, Patrick Chaltin, Aernout Luttun, Dominique Schols
Patents
1 - 1 of 1