Researcher
Thierry VandenDriessche
- Keywords (Vrije Universiteit Brussel):Medicine, Applied biological sciences, biotechnology
- Disciplines (Vrije Universiteit Brussel):Hematology, Neurological and neuromuscular diseases, Cancer therapy, Cardiology, Computational transcriptomics and epigenomics
- Disciplines (KU Leuven):Gene and molecular therapy
- See also: Thierry Vandendriessche (KU Leuven)
Affiliations
- Division of Gene Therapy & Regenerative Medicine (Research group)
Responsible
From19 Apr 2011 → Today - Basic (bio-) Medical Sciences (Department)
Member
From8 Apr 2019 → Today - Basic (bio-) Medical Sciences (Department)
Member
From1 Jan 2014 → 20 Oct 2022 - Cell Biology and Histology (Department)
Member
From1 Oct 2010 → 31 Dec 2013 - Department of Bio-engineering Sciences (Department)
Member
From1 Feb 2010 → 28 Feb 2010 - Immunology and Microbiology (Department)
Member
From1 Oct 2007 → 30 Sep 2010 - Department of Bio-engineering Sciences (Department)
Member
From1 Feb 2007 → 30 Sep 2010 - Department of Bio-engineering Sciences (Department)
Member
From1 Oct 2003 → 30 Sep 2004 - Centre for Molecular and Vascular Biology (Division)
Member
From1 Oct 1999 → Today - Department of General Biology (Research group)
Member
From1 Oct 1990 → 30 Sep 1994
Projects
1 - 10 of 17
- HERCULES: DEVELOPMENT OF NEXT-GENERATION GENE THERAPY TO TREAT GENETIC MUSCLE DISORDERSFrom1 Mar 2024 → TodayFunding: BOF - Methusalem
- HERCULES: Development of an innovative muscle-directed gene therapy platform for lysosomal storage disordersFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- SRP-Groeifinanciering: “RESTORE”: DEVELOPMENT OF INNOVATIVE GENE THERAPIES FOR GENETIC MUSCLE DISORDERSFrom1 Oct 2022 → TodayFunding: BOF - projects
- TREAT-SARCO: Development of a novel gene therapy strategy for sarcoglycan deficiencyFrom1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- UPGRADE: Unlocking Precision Gene TherapyFrom1 Jan 2019 → TodayFunding: H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and wellbeing
- UPGRADE: Unlocking Precision Gene Therapy (OZR EU Bonus)From1 Jan 2019 → 31 Dec 2023Funding: BOF - Other initiatives
- GENEFIX: Development of muscle-targeted gene therapy for hemophilia B using longer-acting clotting factor IXFrom1 Jan 2016 → 31 Dec 2019Funding: FWO research project (including WEAVE projects)
- Advanced T-cell Therapy for Augmented Cancer Killing ("ATTACK"): next-generation T-cell immunotherapy directed against lymphoid malignanciesFrom1 Jan 2016 → 31 Dec 2019Funding: FWO research project (including WEAVE projects)
- Financing IOF-program GEAR: Hyperactieve Expressie-modulesFrom1 Apr 2014 → 31 Mar 2020Funding: IOF - Industrial Research Fund
- SRP (Groeiers): Next-generation gene therapy by computational vector design and immune stealth nanotechnologyFrom1 Mar 2014 → 28 Feb 2019Funding: BOF - Concerted Research Project from 1994
Publications
11 - 20 of 70
- Towards a global multidisciplinary consensus framework on haemophilia gene therapy(2020)
Authors: Glenn F Pierce, K John Pasi, Donna Coffin, Radoslaw Kaczmarek, David Lillicrap, Johnny Mahlangu, Dawn Rottellini, Thomas Sannié, Alok Srivastava, Thierry VandenDriessche, et al.
Pages: 443-449 - Distinct transduction of muscle tissue in mice after systemic delivery of AAVpo1 vectors(2020)
Authors: Warut Tulalamba, Jonas Weinmann, Hong Quang Pham, Jihad El Andari, Thierry VandenDriessche, Marinee K Chuah, Dirk Grimm
Pages: 170-179 - Validation of miR-20a as a Tumor Suppressor Gene in Liver Carcinoma Using Hepatocyte-Specific Hyperactive piggyBac Transposons(2020)
Authors: Jaitip Tipanee, Mario Di Matteo, Warut Tulalamba, Ermira Samara-Kuko, Jiri Keirsse, Jo A Van Ginderachter, Marinee K Chuah, Thierry VandenDriessche
Pages: 1309-1329 - Next-generation muscle-directed gene therapy by in silico vector design(2019)
Authors: Shilpita Sarcar, Warut Tulalamba, Melvin Rincon Acelas, Jaitip Tipanee, Hong Quang Pham, Hanneke Evens, Dimitri Boon, E. Samara-Kuko, M Keyaerts, Mariana Loperfido, et al.
Pages: 492 - Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells(2018)
Authors: Sumitava Dastidar, Simon Ardui, Kshitiz Singh, Debanjana Majumdar, Nisha Nair, Yanfang Fu, Deepak Reyon, Ermira Samara, Mattia FM Gerbil, Arnaud F. Klein, et al.
Pages: 8275-8298 - A Calsequestrin Cis-Regulatory Motif Coupled to a Cardiac Troponin T Promoter Improves Cardiac Adeno-Associated Virus Serotype 9 Transduction Specificity(2018)
Authors: Kyle Chamberlain, Jalish Mahmud Riyad, Tyrone Garnett, Erik Kohlbrenner, Ananda Mookerjee, Firas Elmastour, Ludovic Benard, Jiqiu Chen, Thierry VandenDriessche, Marinee K Chuah, et al.
Pages: 927-937 - Efficient In Vivo Liver-Directed Gene Editing Using CRISPR/Cas9(2018)
Authors: Kshitiz Singh, Hanneke Evens, Nisha Nair, Melvin Rincon Acelas, Shilpita Sarcar, Ermira Samara, Marinee K Chuah, Thierry VandenDriessche
Pages: 1241-1254 - Haemophilia gene therapy(2018)
Authors: Hanneke Evens, Marinee K Chuah, Thierry VandenDriessche
Pages: 50-59 - Hyperactive Factor IX Padua(2018)
Authors: Thierry Vandendriessche, Marinee Chuah
Pages: 14-16 - Preclinical and clinical advances in transposon-based gene therapy(2017)
Authors: Jaitip Tipanee, Yoke Chin Chai, Thierry VandenDriessche, Marinee K Chuah
Patents
1 - 10 of 10
- Muscle-specific nucleic acid regulatory elements and methods and use thereof (Inventor)
- Vectors for liver-directed gene therapy of hemophilia and methods and use thereof (Inventor)
- Novel combination of nucleic acid regulatory elements and methods and uses thereof (Inventor)
- Optimized liver-specific expression systems for fviii and fix (Inventor)
- Novel combination of nucleic acid regulatory elements and methods and uses thereof (Inventor)
- Cardiomyocyte-derived nucleic acid regulatory elements and methods and use thereof (Inventor)
- Vector for liver-directed gene therapy of hemophilia and methods and use thereof (Inventor)
- Endothelium-specific nucleic acid regulatory elements and methods and use thereof (Inventor)
- Muscle-specific nucleic acid regulatory elements and methods and use thereof (Inventor)
- Vector for liver-directed gene therapy of hemophilia and methods and use thereof (Inventor)