Researcher
Stefaan De Smedt
- Keywords:drug delivery, biotherapeutics
- Disciplines:Nanobiotechnology, Environmental safety and health of nanotechnology, Nanoscale characterisation, Nanotechnology not elsewhere classified, Nanometrology, Other pharmaceutical sciences not elsewhere classified, In vitro testing, Biopharmaceuticals, Non-clinical studies, Biopharmaceutics, Pharmaceutical technology, Physical pharmacy, Vaccines, Nanomaterials, Nanomanufacturing, Nanofabrication, growth and self assembly, Nucleic acids, Gene and molecular therapy
Affiliations
- Board of Governors/Executive Board (Administrative office)
Member
From1 Oct 2014 → 30 Sep 2022 - Laboratories of the Faculty of Pharmaceutical Sciences (Administrative office)
Responsible
From1 Oct 2010 → 30 Sep 2014 - Laboratories of the Faculty of Pharmaceutical Sciences (Administrative office)
Member
From1 Oct 2010 → 30 Sep 2014 - Dean's Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Responsible
From1 Oct 2010 → 30 Sep 2014 - Dean's Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Member
From1 Oct 2010 → 30 Sep 2014 - Student Administration Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Responsible
From1 Oct 2010 → 30 Sep 2014 - Student Administration Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Member
From1 Oct 2010 → 30 Sep 2014 - Faculty of Pharmaceutical Sciences (Faculty)
Responsible
From1 Oct 2010 → 30 Sep 2014 - Faculty of Pharmaceutical Sciences (Faculty)
Member
From1 Oct 2010 → 30 Sep 2014 - Department of Pharmaceutics (Department)
Member
From1 Oct 1996 → Today - Department of Pharmaceutical analysis (Department)
Member
From1 Oct 1992 → 30 Sep 1994
Infrastructure
1 - 1 of 1
- Confocal and two-photon Microscope (Consortium partner)
Projects
21 - 30 of 42
- Evaluating the potential of nanomaterials for IP administration of chemotherapeutics and nucleic acids / Nanomedicine: an integrative approachFrom1 Mar 2019 → 31 Aug 2019Funding: BOF - doctoral mandates
- RNA-MAGIC: RNA-based bioMArkers and tarGets In asthma and Chronic Obstructive Pulmonary Disease (COPD)From1 Jan 2019 → TodayFunding: BOF - projects
- Photoporation of the inner limiting membrane to enhance retinal drug delivery after intravitreal injectionFrom1 Oct 2018 → 30 Sep 2022Funding: FWO fellowships
- Strengthening the Research Area of Delivery of Nucleic acid mimics (NAMS) into bacteria to fight the antibiotic crisisFrom1 Aug 2018 → 31 Jan 2022Funding: H2020-EU.4. - Spreading excellence and widening participation
- Laser bench for laser scanning confocal microscopyFrom1 Jun 2018 → 31 May 2020Funding: BOF - Other initiatives
- A basic whole-body bioluminescent and fluorescent in vivo imaging system for small laboratory animalsFrom1 Jun 2018 → 31 May 2020Funding: BOF - Other initiatives
- Liposome loaded microbubbles for the ultrasound triggered release of corticosteroids and TNF-α siRNA in the inflamed synovial tissue during rheumatoid arthritis.From1 Oct 2017 → 30 Sep 2021Funding: BOF - Doctoral projects
- Centre for Advanced Light MicroscopyFrom1 Aug 2017 → 30 Nov 2022Funding: BOF - Doctoral projects
- cytotoxic T cells as transport vehicles for tumor-targeted delivery of nanomedicinesFrom1 Jan 2016 → 30 Jun 2016Funding: FWO Humanitarian research project Stand up against Cancer
- An eco-evolutionary network of biotic interactionsFrom1 Jan 2016 → 31 Dec 2020Funding: FWO scientific research network
Publications
1 - 10 of 71
- Laser-induced vapor nanobubbles for B16-F10 melanoma cell killing and intracellular delivery of chemotherapeutics(2024)
Authors: Jana Ramon, Yanou Engelen, Herlinde De Keersmaecker, Ilia Goemaere, Deep Punj, Julián Mejía Morales, Cédric Bonte, Geert Berx, Esther Hoste, Stephan Stremersch, et al.
Pages: 1019 - 1036 - Nucleic acid degradation as barrier to gene delivery : a guide to understand and overcome nuclease activity(2024)
Authors: Heyang Zhang, Jo Vandesompele, Kevin Braeckmans, Stefaan De Smedt, Katrien Remaut
Pages: 317 - 360 - Repositioning the antihistamine ebastine as an intracellular siRNA delivery enhancer(2023)
Authors: Cristina Muntean, Eva Blondeel, Laure Harinck, Kunal Pednekar, Jai Prakash, Olivier De Wever, Jeanne Leblond Chain, Stefaan De Smedt, Katrien Remaut, Koen Raemdonck
- Principles of antibodies with ultralong complementarity-determining regions and picobodies(2023)
Authors: Marcel Fridolin Passon, Stefaan De Smedt, Hristo Svilenov
- Designing of gradient scaffolds and their applications in tissue regeneration(2023)
Authors: Ananya Pattnaik, A. Swaroop Sanket, Sanghamitra Pradhan, Rajashree Sahoo, Sudiptee Das, Swarnaprbha Pany, Timothy E. L. Douglas, Rambabu Dandela, Qiang Liu, Jaykumar Rajadas, et al.
- Smart hydrogels delivered by high pressure aerosolization can prevent peritoneal adhesions(2023)
Authors: Helena Braet, Peter-Paul Fransen, Yong Chen, Simon Van Herck, Remco Mariën, Valérie Vanhoorne, Wim Ceelen, Annemieke Madder, Steven Ballet, Richard Hoogenboom, et al.
Pages: 138 - 150 - Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8+ T cell and iNKT cell activating mRNA vaccine(2023)
Authors: Thomas Ertveldt, Sofie Meulewaeter, Yannick De Vlaeminck, Oscar Olarte, Katrijn Broos, Serge Van Calenbergh, Stephanie Bourgeois, Joke Deprez, Yves Heremans, Cleo Goyvaerts, et al.
Pages: 5483 - 5500 - The alpha-adrenergic antagonist prazosin promotes cytosolic siRNA delivery from lysosomal compartments(2023)
Authors: Thijs Van de Vyver, Cristina Muntean, Iuliia Efimova, Dmitri Krysko, Lynn De Backer, Stefaan De Smedt, Koen Raemdonck
Pages: 142 - 158 - Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium(2023)
Authors: Joke Deprez, Rein Verbeke, Sofie Meulewaeter, Ilke Aernout, Heleen Dewitte, Tine Decruy, Julie Coudenys, Julie Van Duyse, Gert Van Isterdael, Dan Peer, et al.
Pages: 1341 - 1350 - The effect of electrostatic high pressure nebulization on the stability, activity and ex vivo distribution of ionic self-assembled nanomedicines(2023)
Authors: Helena Braet, Valentina Andretto, Remco Mariën, Beyza Yücesan, Stefan van der Vegte, Ragna Haegebaert, Giovanna Lollo, Stefaan De Smedt, Katrien Remaut
Pages: 318 - 329
Patents
1 - 10 of 10
- MOLECULAR ADJUVANTS FOR ENHANCED CYTOSOLIC DELIVERY OF ACTIVE AGENTS (Inventor)
- PARTICLES COMPRISING SURFACTANT PROTEIN B AND ONE OR MORE LIPIDS (Inventor)
- Composition for treatment of vitreous disease or disorder (Inventor)
- THERAPEUTIC NANOPARTICLES AND METHODS OF USE THEREOF (Inventor)
- Method to increase the permeability of the plasma membrane of cells and a structure suitable for use in such method (Inventor)
- Method and system for characterizing extracellular vesicles (Inventor)
- Composition for treatment of vitreous disease or disorder (Inventor)
- THERAPEUTIC NANOPARTICLES AND METHODS OF USE THEREOF (Inventor)
- Method and system for characterizing extracellular vesicles (Inventor)
- PARTICLES COMPRISING SURFACTANT PROTEIN B AND ONE OR MORE LIPIDS (Inventor)