Researcher
Stefaan De Smedt
- Keywords:drug delivery, biotherapeutics
- Disciplines:Nanobiotechnology, Environmental safety and health of nanotechnology, Nanoscale characterisation, Nanotechnology not elsewhere classified, Nanometrology, Other pharmaceutical sciences not elsewhere classified, In vitro testing, Biopharmaceuticals, Non-clinical studies, Biopharmaceutics, Pharmaceutical technology, Physical pharmacy, Vaccines, Nanomaterials, Nanomanufacturing, Nanofabrication, growth and self assembly, Nucleic acids, Gene and molecular therapy
Affiliations
- Board of Governors/Executive Board (Administrative office)
Member
From1 Oct 2014 → 30 Sep 2022 - Laboratories of the Faculty of Pharmaceutical Sciences (Administrative office)
Responsible
From1 Oct 2010 → 30 Sep 2014 - Laboratories of the Faculty of Pharmaceutical Sciences (Administrative office)
Member
From1 Oct 2010 → 30 Sep 2014 - Dean's Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Responsible
From1 Oct 2010 → 30 Sep 2014 - Dean's Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Member
From1 Oct 2010 → 30 Sep 2014 - Student Administration Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Responsible
From1 Oct 2010 → 30 Sep 2014 - Student Administration Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Member
From1 Oct 2010 → 30 Sep 2014 - Faculty of Pharmaceutical Sciences (Faculty)
Responsible
From1 Oct 2010 → 30 Sep 2014 - Faculty of Pharmaceutical Sciences (Faculty)
Member
From1 Oct 2010 → 30 Sep 2014 - Department of Pharmaceutics (Department)
Member
From1 Oct 1996 → Today - Department of Pharmaceutical analysis (Department)
Member
From1 Oct 1992 → 30 Sep 1994
Infrastructure
1 - 1 of 1
- Confocal and two-photon Microscope (Consortium partner)
Projects
1 - 10 of 42
- A platform for the fast development of thermostable lyophilized mRNA lipid nanoparticle (LNP) vaccinesFrom7 Feb 2024 → TodayFunding: Foreign private sponsor - undefined
- LNP-DECODE: Deciphering the adjuvants activity of lipid nanoparticle-based mRNA vaccines in primary dendritic cellsFrom1 Jan 2024 → TodayFunding: BOF - projects
- Evaluation of formulation parameters o n the mRNA integrity within mRNA lipid nanoparticlesFrom20 Dec 2023 → TodayFunding: IOF - technology validation in lab
- ILM photodisruption: a biophotonic approach to promote retinal ganglion cell engraftment as a cure for blindnessFrom1 Nov 2023 → TodayFunding: FWO senior postdoctoral fellowship
- Immunopeptidomics-based Development of Next-Generation Bacterial mRNA VaccinesFrom1 Jul 2023 → TodayFunding: HORIZON.2.1 - Health
- Laser-induced nanobubbles for advanced therapies in the eye.From1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Flow imaging microscope for advanced analysis of biopharmaceuticals and biological samplesFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Exploring and advancing mRNA lipid nanoparticles for the in situ generation of CAR-MsFrom1 Nov 2022 → TodayFunding: FWO Strategic Basic Research Grant
- Mechanobiology control of immunogenic cell death by bio-polymers for cancer therapyFrom1 Oct 2022 → TodayFunding: BOF - projects
- Understanding and modulating the pro-inflammatory activity of lipid nanoparticles (LNP) in the COVID-19 mRNA vaccines: towards the development of more effective LNP formulations.From1 Oct 2022 → TodayFunding: FWO senior postdoctoral fellowship
Publications
31 - 40 of 71
- High pressure nebulization (PIPAC) versus injection for the intraperitoneal administration of mRNA complexes(2019)
Authors: Molood Shariati, Heyang Zhang, Leen Van de Sande, Benedicte Descamps, Christian Vanhove, Wouter Willaert, Wim Ceelen, Stefaan De Smedt, Katrien Remaut
- Exploring light-sensitive nanocarriers for simultaneous triggered antibiotic release and disruption of biofilms upon generation of laser-induced vapor nanobubbles(2019)
Authors: Eline Teirlinck, Alexandre Barras, Jing Liu, Juan Fraire, Tatu Lajunen, Ranhua Xiong, Katrien Forier, Chengnan Li, Arto Urtti, Rabah Boukherroub, et al.
- The role of ultrasound-driven microbubble dynamics in drug delivery : from microbubble fundamentals to clinical translation(2019)
Authors: Silke Roovers, Tim Segers, Guillaume Lajoinie, Joke Deprez, Michel Versluis, Stefaan De Smedt, Ine Lentacker
Pages: 10173 - 10191 - Comparison of MRI properties between multimeric DOTAGA and DO3A gadolinium-dendron conjugates(2019)
Authors: Maleotane Ndiaye, Volodymyr Malytskyi, Thomas Vangijzegem, Félix Sauvage, Mike Wels, Cyril Cadiou, Juliette Moreau, Céline Henoumont, Sébastien Boutry, Robert N. Muller, et al.
Pages: 12798 - 12808 - Gas‐shearing fabrication of multicompartmental microspheres : a one‐step and oil‐free approach(2019)
Authors: Guosheng Tang, Ranhua Xiong, Dan Lv, Ronald X. Xu, Kevin Braeckmans, Chaobo Huang, Stefaan De Smedt
- Sonoprinting of nanoparticle-loaded microbubbles : unraveling the multi-timescale mechanism(2019)
Authors: Silke Roovers, Guillaume Lajoinie, Ine De Cock, Toon Brans, Heleen Dewitte, Kevin Braeckmans, Michel Versuis, Stefaan De Smedt, Ine Lentacker
- Enhancing nucleic acid delivery with ultrasound and microbubbles(2019)Edition: 2nd ed.Series: Methods in Molecular Biology
Authors: Heleen Dewitte, Silke Roovers, Stefaan De Smedt, Ine Lentacker, Manfred Ogris, Haider Sami
Pages: 241 - 251 - Biocompatible lipid‐coated persistent luminescent nanoparticles for in vivo imaging of dendritic cell migration(2019)
Authors: Aranit Harizaj, Olivier De Clercq, Benedicte Descamps, Christian Vanhove, Stefaan De Smedt, Dirk Poelman, Ine Lentacker, Kevin Braeckmans
- Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms(2018)
Authors: Eline Teirlinck, Ranhua Xiong, Toon Brans, Katrien Forier, Juan Fraire, Heleen Van Acker, Nele Matthijs, Riet De Rycke, Stefaan De Smedt, Tom Coenye, et al.
- Polyimide/cellulose acetate core/shell electrospun fibrous membranes for oil-water separation(2017)
Authors: Wenjing Ma, Zhongfu Guo, Juntao Zhao, Qian Yu, Fang Wang, Jingquan Han, Hui Pan, Jianfeng Yao, Qilu Zhang, Sangram Keshari Samal, et al.
Pages: 71 - 85
Patents
1 - 10 of 10
- MOLECULAR ADJUVANTS FOR ENHANCED CYTOSOLIC DELIVERY OF ACTIVE AGENTS (Inventor)
- PARTICLES COMPRISING SURFACTANT PROTEIN B AND ONE OR MORE LIPIDS (Inventor)
- Composition for treatment of vitreous disease or disorder (Inventor)
- THERAPEUTIC NANOPARTICLES AND METHODS OF USE THEREOF (Inventor)
- Method to increase the permeability of the plasma membrane of cells and a structure suitable for use in such method (Inventor)
- Method and system for characterizing extracellular vesicles (Inventor)
- Composition for treatment of vitreous disease or disorder (Inventor)
- THERAPEUTIC NANOPARTICLES AND METHODS OF USE THEREOF (Inventor)
- Method and system for characterizing extracellular vesicles (Inventor)
- PARTICLES COMPRISING SURFACTANT PROTEIN B AND ONE OR MORE LIPIDS (Inventor)