Researcher
Stefaan De Smedt
- Keywords:drug delivery, biotherapeutics
- Disciplines:Nanobiotechnology, Environmental safety and health of nanotechnology, Nanoscale characterisation, Nanotechnology not elsewhere classified, Nanometrology, Other pharmaceutical sciences not elsewhere classified, In vitro testing, Biopharmaceuticals, Non-clinical studies, Biopharmaceutics, Pharmaceutical technology, Physical pharmacy, Vaccines, Nanomaterials, Nanomanufacturing, Nanofabrication, growth and self assembly, Nucleic acids, Gene and molecular therapy
Affiliations
- Board of Governors/Executive Board (Administrative office)
Member
From1 Oct 2014 → 30 Sep 2022 - Laboratories of the Faculty of Pharmaceutical Sciences (Administrative office)
Responsible
From1 Oct 2010 → 30 Sep 2014 - Laboratories of the Faculty of Pharmaceutical Sciences (Administrative office)
Member
From1 Oct 2010 → 30 Sep 2014 - Dean's Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Responsible
From1 Oct 2010 → 30 Sep 2014 - Dean's Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Member
From1 Oct 2010 → 30 Sep 2014 - Student Administration Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Responsible
From1 Oct 2010 → 30 Sep 2014 - Student Administration Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Member
From1 Oct 2010 → 30 Sep 2014 - Faculty of Pharmaceutical Sciences (Faculty)
Responsible
From1 Oct 2010 → 30 Sep 2014 - Faculty of Pharmaceutical Sciences (Faculty)
Member
From1 Oct 2010 → 30 Sep 2014 - Department of Pharmaceutics (Department)
Member
From1 Oct 1996 → Today - Department of Pharmaceutical analysis (Department)
Member
From1 Oct 1992 → 30 Sep 1994
Infrastructure
1 - 1 of 1
- Confocal and two-photon Microscope (Consortium partner)
Projects
1 - 10 of 42
- A platform for the fast development of thermostable lyophilized mRNA lipid nanoparticle (LNP) vaccinesFrom7 Feb 2024 → TodayFunding: Foreign private sponsor - undefined
- LNP-DECODE: Deciphering the adjuvants activity of lipid nanoparticle-based mRNA vaccines in primary dendritic cellsFrom1 Jan 2024 → TodayFunding: BOF - projects
- Evaluation of formulation parameters o n the mRNA integrity within mRNA lipid nanoparticlesFrom20 Dec 2023 → TodayFunding: IOF - technology validation in lab
- ILM photodisruption: a biophotonic approach to promote retinal ganglion cell engraftment as a cure for blindnessFrom1 Nov 2023 → TodayFunding: FWO senior postdoctoral fellowship
- Immunopeptidomics-based Development of Next-Generation Bacterial mRNA VaccinesFrom1 Jul 2023 → TodayFunding: HORIZON.2.1 - Health
- Laser-induced nanobubbles for advanced therapies in the eye.From1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Flow imaging microscope for advanced analysis of biopharmaceuticals and biological samplesFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Exploring and advancing mRNA lipid nanoparticles for the in situ generation of CAR-MsFrom1 Nov 2022 → TodayFunding: FWO Strategic Basic Research Grant
- Mechanobiology control of immunogenic cell death by bio-polymers for cancer therapyFrom1 Oct 2022 → TodayFunding: BOF - projects
- Understanding and modulating the pro-inflammatory activity of lipid nanoparticles (LNP) in the COVID-19 mRNA vaccines: towards the development of more effective LNP formulations.From1 Oct 2022 → TodayFunding: FWO senior postdoctoral fellowship
Publications
11 - 20 of 71
- CO2-driven nebulization of pH-sensitive supramolecular polymers for intraperitoneal hydrogel formation and the treatment of peritoneal metastasis(2023)
Authors: Helena Braet, Peter-Paul Fransen, Remco Mariën, Giovanna Lollo, Wim Ceelen, Chris Vervaet, Lieve Balcaen, Frank Vanhaecke, Christian Vanhove, Stefan van der Vegte, et al.
Pages: 49022 - 49034 - Laser-induced nanobubbles safely ablate vitreous opacities in vivo(2022)
Authors: Félix Sauvage, Van Phuc Nguyen, Yanxiu Li, Aranit Harizaj, J. Sebag, Dimitri Roels, Viktor Van Havere, Karen Peynshaert, Ranhua Xiong, Juan Fraire, et al.
Pages: 552 - 559 - Non-viral siRNA delivery to T cells : challenges and opportunities in cancer immunotherapy(2022)
Authors: Jelter Van Hoeck, Kevin Braeckmans, Stefaan De Smedt, Koen Raemdonck
- Vapor nanobubble-mediated photoporation constitutes a versatile intracellular delivery technology(2021)
Authors: Jana Ramon, Ranhua Xiong, Stefaan De Smedt, Koen Raemdonck, Kevin Braeckmans
- Concentration gradients in material sciences : methods to design and biomedical applications(2021)
Authors: Dawei Hua, Ranhua Xiong, Kevin Braeckmans, Benoit Scheid, Chaobo Huang, Félix Sauvage, Stefaan De Smedt
- Together is better : mRNA co‐encapsulation in lipoplexes is required to obtain ratiometric co‐delivery and protein expression on the single cell level(2021)
Authors: Heyang Zhang, Jeroen Bussmann, Florian H. Huhnke, Joke Devoldere, An-Katrien Minnaert, Wim Jiskoot, Friedhelm Serwane, Joachim Spatz, Magnus Röding, Stefaan De Smedt, et al.
- Opening doors with ultrasound and microbubbles : beating biological barriers to promote drug delivery(2021)
Authors: Joke Deprez, G. Lajoinie, Yanou Engelen, Stefaan De Smedt, Ine Lentacker
Pages: 9 - 36 - Stimuli-responsive nanobubbles for biomedical applications(2021)
Authors: Ranhua Xiong, Ronald X. Xu, Chaobo Huang, Stefaan De Smedt, Kevin Braeckmans
Pages: 5746 - 5776 - Surface functionalization with polyethylene glycol and polyethyleneimine improves the performance of graphene-based materials for safe and efficient intracellular delivery by laser-induced photoporation(2020)
Authors: Jing Liu, Chengnan Li, Toon Brans, Aranit Harizaj, Shana Van de Steene, Thomas De Beer, Stefaan De Smedt, Sabine Szunerits, Rabah Boukherroub, Ranhua Xiong, et al.
- Intracellular labeling with extrinsic probes : delivery strategies and applications(2020)
Authors: Jing Liu, Juan Fraire, Stefaan De Smedt, Ranhua Xiong, Kevin Braeckmans
Patents
1 - 10 of 10
- MOLECULAR ADJUVANTS FOR ENHANCED CYTOSOLIC DELIVERY OF ACTIVE AGENTS (Inventor)
- PARTICLES COMPRISING SURFACTANT PROTEIN B AND ONE OR MORE LIPIDS (Inventor)
- Composition for treatment of vitreous disease or disorder (Inventor)
- THERAPEUTIC NANOPARTICLES AND METHODS OF USE THEREOF (Inventor)
- Method to increase the permeability of the plasma membrane of cells and a structure suitable for use in such method (Inventor)
- Method and system for characterizing extracellular vesicles (Inventor)
- Composition for treatment of vitreous disease or disorder (Inventor)
- THERAPEUTIC NANOPARTICLES AND METHODS OF USE THEREOF (Inventor)
- Method and system for characterizing extracellular vesicles (Inventor)
- PARTICLES COMPRISING SURFACTANT PROTEIN B AND ONE OR MORE LIPIDS (Inventor)