Researcher

Silvia Amor Barris

Research Expertise (University of Antwerp):My job consist to uncover how loss of functional HINT1 leads to a rare form of peripheral neuropathy. To do so, I work with mammalian cells and yeast to identify disease phenotypes that can help elucidate HINT1's function. The different assays and sutdies I perform include: trasncriptomics, immunoblotting, immunhistochemistry, qPCR, cloning, yeast culture and growth curve analysis, yeast spot assay, iPSCs cultures and differentiations into motoneurons. I also performed CRISPR/Cas9 genome editing technologies to obtain knockout. Most recently I started studying the calcium signaling in different cellular models.

Keywords (University of Antwerp):NEUROMUSCULAR DISEASES, CALCIUM HOMEOSTASIS, STEM CELL PHYSIOLOGY, MODEL SYSTEMS, Pharmacy and pharmacology

Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Behavioural neuroscience
Disciplines (University of Antwerp):Biomarker discovery and evaluation, Drug discovery and development, Medicinal chemistry, Pharmaceutical analysis and quality assurance, Pharmacology, Other pharmaceutical sciences, Other medical and health sciences, Cell signalling, Cytoskeleton, Genetics

Research techniques (University of Antwerp):Immunoblotting, immunohistochemistry, genetics, transcriptomics, yeast culture, cloning, genetic engineering, qPCR.

Users of research expertise (University of Antwerp):Geneticists, clinicians, patients, researchers on CMT