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Researcher
Shehab Ismail Mohamed
- Disciplines:Proteins, Cell signalling, Structural biology
Affiliations
- Biochemistry, Molecular and Structural Biology (Division)
Member
From1 Nov 2020 → Today
Projects
1 - 7 of 7
- Development of KRAS/ PDE6D molecular glues to inhibit KRAS by nucleo-cytoplasmic sequestrationFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Developing 'molecular glues' to target KRAS in cancerFrom18 Oct 2022 → TodayFunding: FWO Strategic Basic Research Grant
- NanoBlocks: nanobody-based biosensors for live-cell imagingFrom1 Oct 2022 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- Development of a new family of genetically-encoded "smart" enzymes based on nanobodiesFrom27 Sep 2022 → 30 Apr 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Single-objective light sheet instrument for fast and highthroughput imaging of 3D tissueFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Delineating ARL functions and regulatorsFrom1 Oct 2021 → TodayFunding: BOF - doctoral mandates
- Delineating Arls functionsFrom1 Nov 2020 → 31 Oct 2022Funding: BOF - projects
Publications
1 - 10 of 10
- Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling(2022)
Authors: Shehab Ismail Mohamed
Pages: 1898 - 1914 - PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness(2021)
Authors: Shehab Ismail Mohamed
- CYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation(2021)
Authors: Shehab Ismail Mohamed
- The Structural and Biochemical Characterization of UNC119B Cargo Binding and Release Mechanisms(2021)
Authors: Shehab Ismail Mohamed
Pages: 1952 - 1963 - An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism(2021)
Authors: Shehab Ismail Mohamed
- Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1(2021)
Authors: Shehab Ismail Mohamed
Pages: 226 - + - ARL3 activation requires the co-GEF BART and effector-mediated turnover(2021)
Authors: Shehab Ismail Mohamed
- Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling(2019)
Authors: Shehab Ismail Mohamed, Max Mazzone
- Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium(2017)
Authors: Shehab Ismail Mohamed, Max Mazzone
Pages: 2373 - 2389 - Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity(2017)
Authors: Andrea Casazza, Shehab Ismail Mohamed, Peter Carmeliet, Max Mazzone
Pages: 14206