Researcher
Savvas Savvides
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Adaptive immunology, Bacteriology
- Disciplines (Ghent University):Molecular biophysics, Biochemistry and metabolism not elsewhere classified, Carbohydrates, Analytical biochemistry, Inorganic elements and compounds, Intracellular compartments and transport, Nucleic acids, Lipids, Other organic elements and compounds, Membrane structure and transport, Cytoskeleton
- See also: Savvas Savvides (Flanders Institute for Biotechnology)
Affiliations
- Savvides Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Biochemistry and microbiology (Department)
Member
From1 Jan 2004 → Today
Projects
1 - 10 of 46
- 'Take 1' on TAOK2: structural insights into TAOK2 and its complexes with TRIM4 and viral dsRNAFrom1 Nov 2023 → TodayFunding: FWO fellowships
- Structural and functional insights into the role of Themis:SHP-1 complexes in inflammationFrom1 Oct 2022 → TodayFunding: FWO senior postdoctoral fellowship
- An integrated approach to unravel eosinophil function in chronic eosinophilic disordersFrom1 Jan 2022 → TodayFunding: FWO EOS
- Rational design of biologics for therapeutic development (FoldCo)From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Targeting transcription factor addiction in acute leukemia (TaTFAL)From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Understanding the immunological basis of persistent airway obstruction in asthmaFrom1 Jan 2021 → TodayFunding: BOF - Methusalem
- Development of small-molecule inhibitors targeting pro-inflammatory and pruritogenic IL-31From15 Jul 2020 → 30 Sep 2022Funding: IOF - technology concept exploration
- Unraveling the structural and functional roles of THEMIS proteins in T cell and B cell development and inflammationFrom1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Engineering and study of peptide-based hydrogels for the sustained release of therapeutic proteins.From1 Nov 2019 → 28 Oct 2023Funding: FWO Strategic Basic Research Grant
- Structural and functional insights into the role of Themis1 and Themis2 in inflammation.From1 Oct 2019 → 30 Sep 2022Funding: FWO junior postdoctoral fellowship
Publications
81 - 90 of 102
- Molecular and structural basis of glutathione import in Gram-positive bacteria via GshT and the cystine ABC importer TcyBC of Streptococcus mutans
Authors: Bjorn Vergauwen, Kenneth Verstraete, Dilani B. Senadheera, Ann Dansercoer, Dennis G. Cvitkovitch, Eric Guedon, Savvas Savvides
Pages: 288 - 303 - Towards structural studies of the old yellow enzyme homologue SYE4 from Shewanella oneidensis and its complexes at atomic resolution
Authors: Jonathan Elegheert, Debbie van den Hemel, Ina Dix, Jan Stout, Jozef Van Beeumen, Ann Brigé, Savvas Savvides
Pages: 85 - 90 - Profiling the biofilm secretome of Burkholderia cenocpepacia in a context of type two secretion system
Authors: Agata Goza, Savvas Savvides, Bart Devreese
Pages: 16 - 16 - Structural basis of IL-23 antagonism by an Alphabody protein scaffold
Authors: Johan Desmet, Kenneth Verstraete, Yehudi Bloch, Eric Lorent, Yurong Wen, Bart Devreese, Karen Vandenbroucke, Stefan Loverix, Thore Hettmann, Sabrina Deroo, et al.
- Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1
Authors: Jonathan Elegheert, Nathalie Bracke, Philippe Pouliot, Irina Gutsche, Alexander V Shkumatov, Nicolas Tarbouriech, Kenneth Verstraete, Wim P Burmeister, Dmitri I Svergun, Bjorn Vergauwen, et al.
Pages: 938 - 947 - Inducible production of recombinant human Flt3 ectodomain variants in mammalian cells and preliminary crystallographic analysis of Flt3 ligand-receptor complexes
Authors: Kenneth Verstraete, Bert Remmerie, Jonathan Elegheert, Guy Haegeman, Peter Vanhoenacker, Kathleen Van Craenenbroeck, Savvas Savvides
Pages: 325 - 331 - Crystallization of an atypical short-chain dehydrogenase from Vibrio vulnificus lacking the conserved catalytic tetrad
Authors: Géraldine Buysschaert, Kenneth Verstraete, Savvas Savvides, Bjorn Vergauwen
Pages: 771 - 774 - The 285 kDa Bap/RTX hybrid cell surface protein (SO4317) of Shewanella oneidensis MR-1 is a key mediator of biofilm formation
Authors: Sofie Theunissen, Lina De Smet, Ann Dansercoer, Bart Motte, Jozef Van Beeumen, Bart Devreese, Savvas Savvides, Bjorn Vergauwen
Pages: 144 - 152 - Glutathione biosynthesis in bacteria by bifunctional GshF is driven by a modular structure featuring a novel hybrid ATP-grasp fold
Authors: Jan Stout, Dirk De Vos, Bjorn Vergauwen, Savvas Savvides
Pages: 486 - 494 - Myristoylated adenylate kinase-2 of Plasmodium falciparum forms a heterodimer with myristoyltransferase
Authors: Stefan Rahlfs, Sasa Koncarevic, Rimma Iozef, Boniface Mwongela Mailu, Savvas Savvides, R. Heiner Schirmer, Katja Becker
Pages: 77 - 84
Patents
1 - 6 of 6
- GALECTIN-10 ANTIBODIES (Inventor)
- NOVEL TSLP INHIBITORS (Inventor)
- GALECTIN-10 ANTIBODIES (Inventor)
- CRYSTAL STRUCTURE OF ATP CITRATE LYASE AND USES THEREOF (Inventor)
- GALECTIN-10 ANTIBODIES (Inventor)
- NOVEL TSLP INHIBITORS (Inventor)