< Back to previous page
Researcher
Sandra Liekens
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Department of Microbiology, Immunology and Transplantation (Department)
Member
From1 Dec 2019 → Today - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → 31 Dec 2019
Projects
1 - 7 of 7
- Structure-based discovery of positive allosteric modulators of the alpha7 nicotinic acetylcholine receptor as cognition enhancers.From1 Oct 2016 → 30 Sep 2018Funding: IOF - Industrial Research Fund
- Vascular-disrupting agents (VDA): mechanism of action and anti-tumor activityFrom1 Feb 2016 → 6 Jan 2017Funding: Own budget, for example: patrimony, inscription fees, gifts
- An automated platform for multiparameter data collection on live pathogens of higher or unknown biosafety risk.From26 Jun 2014 → 31 Dec 2018Funding: Hercules - Large scale research infrastructure
- Role of receptor tyrosine kinases and associated gangliosides in influenza virus replicationFrom1 Oct 2012 → 21 Dec 2020Funding: BOF - Doctoral projects
- Mechanistic study on virus entry and replication. A fundamental approach to the development of new and specific antiviral chemotherapeutics.From1 Jan 2010 → 31 Dec 2014Funding: BOF - Concerted Research Project from 1994
- Dengue virus infection of endothelial cells: Pathogenesis and antiviral potential of glycosaminoglycan targetingFrom1 Sep 2009 → 29 Sep 2015Funding: Own budget, for example: patrimony, inscription fees, gifts
- The effect of Mycoplasma enzymes on the antiviral and anticancer activity of nucleoside analoguesFrom1 Jun 2008 → 2 Dec 2013Funding: IWT personal funding - strategic basic research grants
Publications
101 - 110 of 113
- Synthesis and antiproliferative activity of 2-(([1,2,4]triazolo[4,3-b]-pyridazin-6-yloxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine derivatives(2011)
Authors: Sandra Liekens
Pages: 309 - 322 - Novel pyrazole derivatives: synthesis and evaluation of anti-angiogenic activity(2010)
Authors: Sandra Liekens
Pages: 4338 - 50 - Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use(2010)
Authors: Jan Balzarini, Kristel Van Laethem, Bart Hoorelbeke, Marleen Renders, Sandra Liekens, Dominique Schols
Pages: 1425 - 1435 - The COOH-Terminal Peptide of Platelet Factor-4 Variant (CXCL4L1/PF-4var(47-70)) Strongly Inhibits Angiogenesis and Suppresses B16 Melanoma Growth In vivo(2010)
Authors: Jo Vandercappellen, Sandra Liekens, Sam Noppen, Paul Proost, Sofie Struyf, Jo Van Damme
Pages: 322 - 334 - CXCL12-CXCR4 Axis in Angiogenesis, Metastasis and Stem Cell Mobilization(2010)
Authors: Sandra Liekens, Dominique Schols, Sigrid Hatse
Pages: 3903 - 20 - Role of thymidine phosphorylase/platelet-derived endothelial cell growth factor in tumor progression(2009)
Authors: Sandra Liekens
Pages: 67 - 79 - The dual role of thymidine phosphorylase in cancer development and chemotherapy(2009)
Authors: Annelies Bronckaers, Jan Balzarini, Sandra Liekens
Pages: 903 - 953 - Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule "crystallization chaperone" 5'-O-tritylinosine (KIN59)(2009)
Authors: Annelies Bronckaers, Jan Balzarini, Sandra Liekens
Pages: 231 - 240 - Improvement of purine and pyrimidine antimetabolite-based anticancer treatment by selective suppression of mycoplasma-encoded catabolic enzymes(2009)
Authors: Sandra Liekens, Annelies Bronckaers, Jan Balzarini
Pages: 628 - 635 - Pradimicin-Sis a Highly Soluble Non-peptidic Small-size Carbohydrate-binding Antibiotic that may Qualify as a Potential Drug Lead for HIV Treatment(2009)
Authors: Jan Balzarini, K Francois, Kristel Van Laethem, Bart Hoorelbeke, Joeri Auwerx, Sandra Liekens, Y Igarashi, T Oki, Dominique Schols
Pages: A44 - A44
Patents
1 - 2 of 2
- Novel anti-cancer thiophene compounds (Inventor)
- Anti-cancer compounds (Inventor)