Researcher

Rosa Rademakers

Research Expertise (University of Antwerp):Frontotemporal Dementia (FTD) represents 10-20% of all dementias and is clinically important because of its early onset and its dramatic impact on core human qualities, including personality, insight and verbal communication. Research in our group is focused on the discovery and functional characterization of novel disease genes implicated in FTD and related disorders. Our group leads world-wide consortia focused on two important pathological subtypes of FTD. Starting from blood or brain tissue samples, we combine genomic, transcriptomic, epigenomic and proteomic analyses to identify genes and pathways implicated in disease. We also leverage our genetic findings to further the understanding of FTD and related disorders through the generation of cell and mouse models. Together our findings provide new insight into the pathomechanisms underlying FTD and contribute to the development of biomarkers and to the identification new targets for neurodegenerative disease therapies.

Keywords (University of Antwerp):NEUROGENETICS, NEURODEGENERATION, FRONTOTEMPORAL DEMENTIA, Chemistry (incl. biochemistry)

Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Behavioural neuroscience
Disciplines (University of Antwerp):Analysis of next-generation sequence data, Bioinformatics data integration and network biology, Bioinformatics of disease, Computational transcriptomics and epigenomics, Development of bioinformatics software, tools and databases, Single-cell data analysis, Genetics, Neurological and neuromuscular diseases

Research techniques (University of Antwerp):Genetics, epigenetics, bioinformatics, cell- and mouse models

Users of research expertise (University of Antwerp):Basic and Clinical Research scientists