< Back to previous page

Researcher

Renzo Mancuso

  • Research Expertise:Microglia and neuroinflammation play a central role in the pathogenesis of Alzheimer’s disease and other neurodegenerative disorders. Our primary focus is to examine the underlying molecular mechanisms that drive Alzheimer’s disease (AD) and Frontotemporal degeneration (FTD), with special focus on inflammatory networks and particularly the contribution of microglia. We use mouse models, iPSC and cutting-edge humanised mouse systems to determine the immune component of these disorders and determine how genetics alter microglial function and contribute to the initiation and perpetuation of brain disease.
  • Keywords:ALZHEIMER'S DISEASE, INDUCED PLURIPOTENT STEM CELLS, NEUROINFLAMMATION, TRANSCRIPTOMICS, MICROGLIA, Applied biological sciences, biotechnology
  • Disciplines:Inflammation, Innate immunity, Neurological and neuromuscular diseases
  • Research techniques:Microglia biology iPSC biology Single cell transcriptomics Flow cytometry Mouse models Xenotransplantation Neurophatology
  • Users of research expertise:Academic groups working on neuroscience, neuroinflammation and microglia biology. Companies in the biomedical field