Researcher
Rafaela Gladysz
- Keywords:Pharmacy and pharmacology
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal chemistry, Medicinal products, Pharmaceutical analysis and quality assurance, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Other medical and health sciences
Affiliations
- Medicinal Chemistry (UAMC) (Research group)
Member
From1 Nov 2019 → 31 Oct 2020 - Medicinal Chemistry (UAMC) (Research group)
Member
From1 Oct 2016 → 30 Sep 2019 - Medicinal Chemistry (UAMC) (Research group)
Member
From1 Jan 2016 → 30 Sep 2016 - Medicinal Chemistry (UAMC) (Research group)
Member
From1 Oct 2010 → 31 Dec 2015
Projects
1 - 4 of 4
- Target-guided synthesis (TGS) of enzyme inhibitors via a two-component cyclocondensation using urokinase plasminogen activator (uPA) as a model target.From1 Apr 2017 → 31 Mar 2018Funding: BOF - Other initiatives
- On-target assembly of druglike small molecules as protease inhibitors: a bottom-up approach using urokinase plasminogen activator (uPA) as a model target.From1 Oct 2016 → 30 Sep 2019Funding: FWO fellowships
- Active center assisted selection and assembly: a bottom-up approach to druglike protease inhibitors using urokinase plasminogen activator as a model target.From1 Jan 2012 → 31 Dec 2015Funding: IWT personal funding - strategic basic research grants
- Active center assisted selection and assembly: a bottom-up approach to druglike protease inhibitors using urokinase plasminogen activator as a model target.From1 Jan 2011 → 31 Dec 2011Funding: BOF - Other initiatives
Publications
1 - 8 of 8
- Efforts towards an on‐target version of the Groebke‐Blackburn‐Bienaymé (GBB) reaction for discovery of druglike urokinase (uPA) inhibitors(2019)
Authors: Rafaela Gladysz, Johannes Vrijdag, Dries Van Rompaey, Anne-Marie Lambeir, Koen Augustyns, Hans De Winter, Pieter Van Der Veken
Pages: 12380 - 12393 - Spectrophores as one-dimensional descriptors calculated from three-dimensional atomic properties: applications ranging from scaffold hopping to multi-target virtual screening(2018)
Authors: Rafaela Gladysz, Fabio Mendes Dos Santos, Wilfried Langenaeker, Gert Thijs, Koen Augustyns, Hans De Winter
- Fragment-based approaches to inhibitors of urokinase plasminogen activator (uPA)(2016)
Authors: Rafaela Gladysz
Number of pages: 219 - Substrate activity screening (SAS) and related approaches in medicinal chemistry(2016)
Authors: Rafaela Gladysz, Anne-Marie Lambeir, Jurgen Joossens, Koen Augustyns, Pieter Van Der Veken
Pages: 467 - 476 - Inhibitor screening and enzymatic activity determination for autophagy target Atg4B using a gel electrophoresis-based assay(2016)
Authors: Matthias Cleenewerck, Mandy Grootaert, Rafaela Gladysz, Yves Adriaenssens, Ria Roelandt, Jurgen Joossens, Anne-Marie Lambeir, Guido De Meyer, Wim Declercq, Koen Augustyns, et al.
Pages: 631 - 638 - The first potent diphenyl phosphonate KLK4 inhibitors with unexpected binding kinetics(2015)
Authors: Jeroen van Soom, Giuliana Cuzzucoli Crucitti, Rafaela Gladysz, Pieter Van Der Veken, Roberto Di Santo, Ingmar Stuyver, Victoria Buck, Viktor Magdolen, Jurgen Joossens, Koen Augustyns
Pages: 1954 - 1958 - Discovery and SAR of novel and selective inhibitors of urokinase plasminogen activator (uPA) with an imidazo[1,2-a]pyridine scaffold(2015)
Authors: Rafaela Gladysz, Yves Adriaenssens, Hans De Winter, Jurgen Joossens, Koen Augustyns, Pieter Van Der Veken
Pages: 9238 - 9257 - Repositioning the Substrate Activity Screening (SAS) approach as a fragment-based method for identification of weak binders(2014)
Authors: Rafaela Gladysz, Matthias Cleenewerck, Jurgen Joossens, Koen Augustyns, Pieter Van Der Veken
Pages: 2238 - 2247