Researcher
Pieter Mestdagh
- Keywords:oncology, transcriptomics, RNA, non-coding RNA
- Disciplines:Analysis of next-generation sequence data, Cancer diagnosis, Cancer therapy, Molecular diagnostics, Development of bioinformatics software, tools and databases, Computational transcriptomics and epigenomics, Bioinformatics of disease, Bioinformatics data integration and network biology, Cancer biology, Transcription and translation, Epigenetics, Genome structure and regulation, Genetics
Affiliations
- Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Department of Pediatrics and medical genetics (Department)
Member
From1 Oct 2006 → 30 Sep 2018
Projects
1 - 10 of 38
- Plasma cfRNA biomarker tail genes for cancer screening and monitoringFrom15 Oct 2023 → TodayFunding: IOF - technology concept exploration
- Increasing the value proposition of the IOF programs CRISParray and Amalus: CRISPRi-based target deconvolution of fibroblast modulatorsFrom15 Jul 2023 → TodayFunding: IOF - technology validation in lab
- Integration of molecular and cellular phenotypes: Optimizing complementarity of RNA-Seq and High Content Microscopy for the CRISParray platformFrom1 May 2023 → TodayFunding: IOF - technology concept exploration
- A new photoelectrochemical singlet oxygen-based detection platform for a panel of cancer biomarkers in tissue and liquid biopsies (SOCAN)From1 Jan 2023 → TodayFunding: BOF - iBOF
- Identifying lncRNA modulators of T-cell activation to enhance immune-checkpoint inhibition therapyFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Long non-coding RNA modulators of tumor immune evasionFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Incucyte S3: Comprehensive cellular phenotyping using high-throughput live cell imagingFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Functional study of a novel, long non-coding RNA (lncRNA) upstream of ABCA4 in retina and blindnessFrom1 Nov 2022 → TodayFunding: BOF - doctoral mandates
- Mapping and disrupting molecular interactions with the long non-coding RNA NESPR in neuroblastomaFrom1 Oct 2022 → TodayFunding: BOF - postdoctoral mandates
- CRISParray : accelerating drug discovery through comprehensive cellular and molecular phenotypingFrom1 Aug 2022 → TodayFunding: IWT / VLAIO personal funding - innovation mandates
Publications
41 - 50 of 261
- Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development(2020)
Authors: Anne-Catherine Dolens, Kaat Durinck, Marieke Lavaert, Joni Van der Meulen, Imke Velghe, Jelle De Medts, Karin Weening, Juliette Roels, Katrien De Mulder, Pieter-Jan Volders, et al.
- The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35(2019)
Authors: Pei Y Liu, Andrew E Tee, Giorgio Milazzo, Katherine M Hannan, Jesper Maag, Sujanna Mondal, Bernard Atmadibrata, Nenad Bartonicek, Hui Peng, Nicholas Ho, et al.
- Dramatic differences in RNA purification kit performance in the extracellular RNA quality control study : important considerations for liquid biopsies(2019)
Authors: Francisco Avila Cobos, Carolina Fierro, Hetty Helsmoortel, An Hendrix, Eva Hulstaert, Scott Kuersten, Pieter Mestdagh, Nele Nijs, Justine Nuytens, Annouck Philippron, et al.
Number of pages: 1 - Benchmarking the impact of data transformation, pre-processing and choice of method in the computational deconvolution of transcriptomics data(2019)
Authors: Francisco Avila Cobos, José Alquicira-Hernandez, Jo Vandesompele, Joseph Powell, Pieter Mestdagh, Katleen De Preter
Number of pages: 1 - Lack of adequate reporting of pre-analytical variables in RNA based liquid biopsies studies hampers quality assessment and replication(2019)
Authors: Pieter Mestdagh, Céleste Van Der Schueren, Hetty Helsmoortel, Eva Hulstaert
Number of pages: 1 - Integrative analysis identifies lincRNAs up- and downstream of neuroblastoma driver genes(2019)
Authors: Dries Rombaut, Hua-Sheng Chiu, Bieke Decaesteker, Agathe Pelthier, Isabelle Janoueix, Christophe Bartenhagen, Matthias Fischer, Stephen Roberts, Nicky D'Haene, Geertrui Denecker, et al.
- SMARTer single cell total RNA sequencing(2019)
Authors: Karen Verboom, Nathalie Bolduc, Kenneth Livak, Dries Rombaut, Morten Venø, Jørgen Kjems, Pieter Mestdagh
Number of pages: 1 - SMARTer single cell total RNA-sequencing(2019)
Authors: Karen Verboom, Celine Everaert, Nathalie Bolduc, Kenneth Livak, Nurten Yigit, Dries Rombaut, Jasper Anckaert, Simon Lee, Morten Venø, Jørgen Kjems, et al.
- The generation and use of recombinant extracellular vesicles as biological reference material(2019)
Authors: Edward Geeurickx, Joeri Tulkens, Bert Dhondt, Jan Van Deun, Lien Lippens, Glenn Vergauwen, Elisa Heyrman, Delphine De Sutter, Kris Gevaert, Francis Impens, et al.
- Plasma miRNAs as biomarkers for endometriosis(2019)
Authors: A. Vanhie, D. Peterse, A. Beckers, A. Cuellar, A. Fassbender, C. Meuleman, Pieter Mestdagh, T. D'Hooghe
Pages: 1650 - 1660
Patents
1 - 9 of 9
- Inhibition of a lncRNA for treatment of neuroblastoma (Inventor)
- Inhibition of a lncRNA for treatment of melanoma (Inventor)
- Combinations of therapeutic agents for treating uveal melanoma (Inventor)
- Biomarkers for disease burden of neuroblastoma (Inventor)
- Usages of recombinant extracellular vesicles (Inventor)
- Inhibition of a lncRNA for treatment of neuroblastoma (Inventor)
- Biomarkers for disease burden of neuroblastoma (Inventor)
- Usages of recombinant extracellular vesicles (Inventor)
- Inhibition of a lncRNA for treatment of melanoma (Inventor)