Researcher
Pieter Mestdagh
- Keywords:oncology, transcriptomics, RNA, non-coding RNA
- Disciplines:Analysis of next-generation sequence data, Cancer diagnosis, Cancer therapy, Molecular diagnostics, Development of bioinformatics software, tools and databases, Computational transcriptomics and epigenomics, Bioinformatics of disease, Bioinformatics data integration and network biology, Cancer biology, Transcription and translation, Epigenetics, Genome structure and regulation, Genetics
Affiliations
- Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Department of Pediatrics and medical genetics (Department)
Member
From1 Oct 2006 → 30 Sep 2018
Projects
1 - 10 of 38
- Plasma cfRNA biomarker tail genes for cancer screening and monitoringFrom15 Oct 2023 → TodayFunding: IOF - technology concept exploration
- Increasing the value proposition of the IOF programs CRISParray and Amalus: CRISPRi-based target deconvolution of fibroblast modulatorsFrom15 Jul 2023 → TodayFunding: IOF - technology validation in lab
- Integration of molecular and cellular phenotypes: Optimizing complementarity of RNA-Seq and High Content Microscopy for the CRISParray platformFrom1 May 2023 → TodayFunding: IOF - technology concept exploration
- A new photoelectrochemical singlet oxygen-based detection platform for a panel of cancer biomarkers in tissue and liquid biopsies (SOCAN)From1 Jan 2023 → TodayFunding: BOF - iBOF
- Identifying lncRNA modulators of T-cell activation to enhance immune-checkpoint inhibition therapyFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Long non-coding RNA modulators of tumor immune evasionFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Incucyte S3: Comprehensive cellular phenotyping using high-throughput live cell imagingFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Functional study of a novel, long non-coding RNA (lncRNA) upstream of ABCA4 in retina and blindnessFrom1 Nov 2022 → TodayFunding: BOF - doctoral mandates
- Mapping and disrupting molecular interactions with the long non-coding RNA NESPR in neuroblastomaFrom1 Oct 2022 → TodayFunding: BOF - postdoctoral mandates
- CRISParray : accelerating drug discovery through comprehensive cellular and molecular phenotypingFrom1 Aug 2022 → TodayFunding: IWT / VLAIO personal funding - innovation mandates
Publications
31 - 40 of 261
- Substantial performance differences among RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study(2021)
Authors: Anneleen Decock, Olivier De Wever, Celine Everaert, Hetty Helsmoortel, An Hendrix, Pieter Mestdagh, Annelien Morlion, Jo Vandesompele, Ruben Van Paemel, Francisco Avila Cobos, et al.
Number of pages: 1 - Checkpoint inhibition in combination with an immunoboost of external beam radiotherapy in solid tumors (CHEERS) : study protocol for a phase 2, open-label, randomized controlled trial(2021)
Authors: Mathieu Spaas, Nora Sundahl, Eva Hulstaert, Vibeke Kruse, Daan De Maeseneer, Annabel Meireson, Lieve Brochez, Dries Reynders, Els Goetghebeur, Robbe Van den Begin, et al.
- The RNA Atlas expands the catalog of human non-coding RNAs(2021)
Authors: Lucia Lorenzi, Hua-Sheng Chiu, Francisco Avila Cobos, Stephen Gross, Pieter-Jan Volders, Robrecht Cannoodt, Justine Nuytens, Katrien Vanderheyden, Jasper Anckaert, Steve Lefever, et al.
Pages: 1453 - 1465 - Substantial performance differences among RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control study-important considerations for liquid biopsies(2020)Volume: 26
Authors: Anneleen Decock, Jasper Anckaert, Celine Everaert, Justine Nuytens, Scott Kuersten, An Hendrix, Jo Vandesompele, Pieter Mestdagh, Bert Dhondt, Ruben Van Paemel, et al.
Pages: 93 - 94 - SPECS: a non-parametric method to identify tissue-specific molecular features for unbalanced sample groups(2020)
Authors: Celine Everaert, Pieter-Jan Volders, Annelien Morlion, Olivier Thas, Pieter Mestdagh
- Benchmarking of cell type deconvolution pipelines for transcriptomics data(2020)
Authors: Francisco Avila Cobos, José Alquicira-Hernandez, Joseph E. Powell, Pieter Mestdagh
- The role of miR-155 in cigarette smoke-induced pulmonary inflammation and COPD(2020)
Authors: Hannelore Van Eeckhoutte, Francisco Avila Cobos, Fien Verhamme, Sharen Provoost, STIJN VERLEDEN, Pieter Mestdagh
Pages: 423 - 436 - Vapor nanobubble is the more reliable photothermal mechanism for inducing endosomal escape of siRNA without disturbing cell homeostasis(2020)
Authors: Juan Fraire, Gaëlle Houthaeve, Jing Liu, Laurens Raes, Lotte Vermeulen, Stephan Stremersch, Toon Brans, Gerardo Garcia-Diaz Barriga, Sarah De Keulenaer, Filip Van Nieuwerburgh, et al.
Pages: 262 - 275 - Performance assessment of total RNA sequencing of human biofluids and extracellular vesicles(2020)Volume: 26
Authors: Celine Everaert, Hetty Helsmoortel, Anneleen Decock, Eva Hulstaert, Ruben Van Paemel, Kimberly Verniers, Justine Nuytens, Jasper Anckaert, Nele Nijs, Joeri Tulkens, et al.
Pages: 94 - 95 - When DNA gets in the way : a cautionary note for DNA contamination in extracellular RNA-seq studies(2020)
Authors: Jasper Verwilt, Ruben Van Paemel, MD Giraldez, Pieter Mestdagh
Pages: 18934 - 18936
Patents
1 - 9 of 9
- Inhibition of a lncRNA for treatment of neuroblastoma (Inventor)
- Inhibition of a lncRNA for treatment of melanoma (Inventor)
- Combinations of therapeutic agents for treating uveal melanoma (Inventor)
- Biomarkers for disease burden of neuroblastoma (Inventor)
- Usages of recombinant extracellular vesicles (Inventor)
- Inhibition of a lncRNA for treatment of neuroblastoma (Inventor)
- Biomarkers for disease burden of neuroblastoma (Inventor)
- Usages of recombinant extracellular vesicles (Inventor)
- Inhibition of a lncRNA for treatment of melanoma (Inventor)