Researcher
Pieter Mestdagh
- Keywords:oncology, transcriptomics, RNA, non-coding RNA
- Disciplines:Analysis of next-generation sequence data, Cancer diagnosis, Cancer therapy, Molecular diagnostics, Development of bioinformatics software, tools and databases, Computational transcriptomics and epigenomics, Bioinformatics of disease, Bioinformatics data integration and network biology, Cancer biology, Transcription and translation, Epigenetics, Genome structure and regulation, Genetics
Affiliations
- Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Department of Pediatrics and medical genetics (Department)
Member
From1 Oct 2006 → 30 Sep 2018
Projects
1 - 10 of 38
- Plasma cfRNA biomarker tail genes for cancer screening and monitoringFrom15 Oct 2023 → TodayFunding: IOF - technology concept exploration
- Increasing the value proposition of the IOF programs CRISParray and Amalus: CRISPRi-based target deconvolution of fibroblast modulatorsFrom15 Jul 2023 → TodayFunding: IOF - technology validation in lab
- Integration of molecular and cellular phenotypes: Optimizing complementarity of RNA-Seq and High Content Microscopy for the CRISParray platformFrom1 May 2023 → TodayFunding: IOF - technology concept exploration
- A new photoelectrochemical singlet oxygen-based detection platform for a panel of cancer biomarkers in tissue and liquid biopsies (SOCAN)From1 Jan 2023 → TodayFunding: BOF - iBOF
- Identifying lncRNA modulators of T-cell activation to enhance immune-checkpoint inhibition therapyFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Long non-coding RNA modulators of tumor immune evasionFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Incucyte S3: Comprehensive cellular phenotyping using high-throughput live cell imagingFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Functional study of a novel, long non-coding RNA (lncRNA) upstream of ABCA4 in retina and blindnessFrom1 Nov 2022 → TodayFunding: BOF - doctoral mandates
- Mapping and disrupting molecular interactions with the long non-coding RNA NESPR in neuroblastomaFrom1 Oct 2022 → TodayFunding: BOF - postdoctoral mandates
- CRISParray : accelerating drug discovery through comprehensive cellular and molecular phenotypingFrom1 Aug 2022 → TodayFunding: IWT / VLAIO personal funding - innovation mandates
Publications
21 - 30 of 261
- Robust sequential biophysical fractionation of blood plasma to study variations in the biomolecular landscape of systemically circulating extracellular vesicles across clinical conditions(2021)
Authors: Glenn Vergauwen, Joeri Tulkens, Francisco Avila Cobos, Marie-Angélique De Scheerder, Ilkka Miinalainen, Pieter Mestdagh, Hannelore Denys, An Hendrix
- Evaluating diagnostic accuracy of saliva sampling methods for severe acute respiratory syndrome coronavirus 2 reveals differential sensitivity and association with viral load(2021)
Authors: Pieter Mestdagh, Michel Gillard, Sharonjit K. Dhillon, Jean-Paul Pirnay, Jeroen Poels, Jan Hellemans, Veronik Hutse, Celine Vermeiren, Maxime Boutier, Veerle De Wever, et al.
Pages: 1249 - 1258 - RNAcentral 2021 : secondary structure integration, improved sequence search and new member databases(2021)
Authors: Blake A. Sweeney, I Petrov, Anton, Carlos E. Ribas, Robert D. Finn, Alex Bateman, Maciej Szymanski, Wojciech M. Karlowski, Stefan E. Seemann, Jan Gorodkin, Jamie J. Cannone, et al.
Pages: D212 - D220 - Genome-wide study of the effect of blood collection tubes on the cell-free DNA methylome(2021)
Authors: Ruben Van Paemel, Andries De Koker, Christa Caggiano, Pieter Mestdagh
Pages: 797 - 807 - The RNA Atlas expands the catalog of human non-coding RNAs (June, 10.1038/s41587-021-00936-1, 2021)(2021)
Authors: Lucia Lorenzi, Hua-Sheng Chiu, Francisco Avila Cobos, Stephen Gross, Justine Nuytens, Katrien Vanderheyden, Aidan Tay, Eric J. de Bony, Fien Gysens, Marieke Vromman, et al.
Pages: 1467 - 1467 - The MicroRNA landscape of acute beta cell destruction in type 1 diabetic recipients of intraportal islet grafts(2021)
Authors: Geert Martens, Geert Stangé, Lorenzo Piemonti, Zhidong Ling, Daniel G. Pipeleers, Frans K. Gorus, Pieter Mestdagh, Dieter De Smet, Bart Keymeulen, Sarah Roels
- Recurrent chromosomal imbalances provide selective advantage to human embryonic stem cells under enhanced replicative stress conditions(2021)
Authors: Liselot Mus, Stéphane Van Haver, Mina Popovic, Wim Trypsteen, Steve Lefever, Nadja Zeltner, Yudelca Ogando, Eva Jacobs, Geertrui Denecker, Ellen Sanders, et al.
Pages: 272 - 281 - A microRNA-21–mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis(2021)
Authors: Richard Y. Kim, Krishna P. Sunkara, Ken R. Bracke, Andrew G. Jarnicki, Chantal Donovan, Alan C. Hsu, Antonio Ieni, Emma L. Beckett, Izabela Galvão, Sara Wijnant, et al.
- Targeted therapy of TERT-rearranged neuroblastoma with BET bromodomain inhibitor and proteasome inhibitor combination therapy(2021)
Authors: Jingwei Chen, Christopher Nelson, Matthew Wong, Andrew E. Tee, Pei Y. Liu, Ting La, Jamie I. Fletcher, Alvin Kamili, Chelsea Mayoh, Christoph Bartenhagen, et al.
Pages: 1438 - 1451 - Substantial performance differences among RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study(2021)
Authors: Anneleen Decock, Olivier De Wever, Celine Everaert, Hetty Helsmoortel, An Hendrix, Pieter Mestdagh, Annelien Morlion, Jo Vandesompele, Ruben Van Paemel, Francisco Avila Cobos, et al.
Number of pages: 1
Patents
1 - 9 of 9
- Inhibition of a lncRNA for treatment of neuroblastoma (Inventor)
- Inhibition of a lncRNA for treatment of melanoma (Inventor)
- Combinations of therapeutic agents for treating uveal melanoma (Inventor)
- Biomarkers for disease burden of neuroblastoma (Inventor)
- Usages of recombinant extracellular vesicles (Inventor)
- Inhibition of a lncRNA for treatment of neuroblastoma (Inventor)
- Biomarkers for disease burden of neuroblastoma (Inventor)
- Usages of recombinant extracellular vesicles (Inventor)
- Inhibition of a lncRNA for treatment of melanoma (Inventor)