Researcher
Paul Cos
- Research Expertise:In vitro and in vivo biofilm assays, Integrated antimicrobial (bacteria, fungi, yeasts and parasites) screening and profiling of pure compounds and extracts, targeting redox homeostasis in mycobacteria
- Keywords:MICROBIOLOGY, BACTERIOLOGY, BIOFILMS, INFLAMMATION, Pharmacy and pharmacology
- Disciplines:Microbiology, Systems biology, Laboratory medicine
- Research techniques:In vitro and in vivo (pre-clinical) models of infectious diseases (bacteria and fungi), evaluation of drugs
- Users of research expertise:Pharmaceutical companies (big pharma, SME, spin-off), news agencies, journalists, government agencies, regulatory (EU) agencies, non-governmental organisations in the field of infectious diseases
Affiliations
- Laboratory for Microbiology, Parasitology and Hygiene (LMPH) (Research group)
Responsible
From1 Oct 2020 → Today - Laboratory for Microbiology, Parasitology and Hygiene (LMPH) (Research group)
Member
From1 Oct 2006 → 30 Sep 2020
Projects
31 - 40 of 59
- Primary and secondary in vitro evaluation of compounds against visceral leishmaniasis, human African trypanosomiasis and Chagas disease.From1 Nov 2015 → 31 Dec 2021Funding: Foreign foundations, funds with scientific view
- Medicinal Chemistry-Drug Discovery (ADDN).From1 Jan 2015 → 31 Dec 2020Funding: IOF - mandates, IOF - Industrial Research Fund
- Elucidating the mechanism of action of octahydrobenzo[j] phenanthridinediones as novel potent antimycobacterialcompounds.From1 Oct 2014 → 30 Sep 2017Funding: FWO fellowships
- Pathogenetic role of endothelial nitric oxide synthase uncoupling in ischemia- and reperfusion injury of the lung.From1 Oct 2014 → 30 Sep 2016Funding: FWO fellowships
- Study of miltefosine resistance mechanisms and dynamics through experimental selection of miltefosine-resistant Leishmania amastigo.From1 Oct 2014 → 30 Sep 2016Funding: FWO fellowships
- Modelling microbial growth during solid state fermentationFrom1 Jul 2014 → 31 Dec 2015Funding: BOF - Other initiatives
- Exploration of the biodiversity of Brazil to identify and evaluate novel bioactive compounds and extracts against infectious tropical diseases.From1 Feb 2014 → 31 Jan 2016Funding: Foreign public sponsor
- Creation of a preclinical platform at the UA for testing novel therapeutic approaches against ocular surface diseases.From1 Jan 2014 → 31 Dec 2015Funding: IOF - Industrial Research Fund
- Biopharmaceutical products from natural sources to biotechnological development.From1 Apr 2013 → 31 Mar 2019Funding: VLIR-UOS Institutional University Cooperation Program (IUC)
- Induction of miltefosine (MIL)-resistance on Leishmania amastigotes: study of the effect of resistance on MIL-internalisation, processing and parasitic fitness.From1 Jan 2013 → 31 Dec 2016Funding: IWT personal funding - strategic basic research grants
Publications
1 - 10 of 272
- A high-throughput target-based screening approach for the identification and assessment of Mycobacterium tuberculosis mycothione reductase inhibitors(2024)
Authors: Natalia Smiejkowska, Lauren Oorts, Linda De Vooght, Rob Geens, Henri-Philippe Mattelaer, Koen Augustyns, Sergei V. Strelkov, Dirk Lamprecht, Koen Temmerman, Yann Sterckx, et al.
Pages: 1 - 22 - In vitro modelling of bacterial pneumonia(2024)
Authors: Laure Mahieu, Laurence Van Moll, Linda De Vooght, Peter Delputte, Paul Cos
Pages: 1 - 23 - All eyes on the prefusion-stabilized F construct, but are we missing the potential of alternative targets for respiratory syncytial virus vaccine design?(2024)
Authors: Lotte Jacobs, Kim Stobbelaar, Paul Cos, Peter Delputte
Pages: 1 - 27 - Bioinsecticide potential of ethanol extracts from Persea americana (Lauraceae) seeds on Aedes aegypti mosquitoes(2023)
Authors: Silvia Molina Bertrán, Idelsy Chil-Nunez, Julio Cesar Escalona-Arranz, Raimundo Nonato Picanco-Souto, Alejandro Felipe Gonzalez, Jesus Garcia Diaz, Paul Cos, Gabriel Llauradó Maury, Humberto Joaquin Morris-Quevedo
Pages: 404 - 414 - Selected strategies to fight pathogenic bacteria(2023)
Authors: Aiva Plotniece, Arkadij Sobolev, Claudiu T. Supuran, Fabrizio Carta, Fredrik Björkling, Henrik Franzyk, Jari Yli-Kauhaluoma, Koen Augustyns, Paul Cos, Linda De Vooght, et al.
Pages: 1 - 27 - Expanding the squaramide library as mycobacterial ATP synthase inhibitors(2023)
Authors: Jan Chasák, Lauren Oorts, Milan Dak, Veronika Šlachtová, Václav Bazgier, Karel Berka, Linda De Vooght, Natalia Smiejkowska, Laurence Van Moll, Davie Cappoen, et al.
Pages: 1 - 18 - Acyloxymethyl and alkoxycarbonyloxymethyl prodrugs of a fosmidomycin surrogate as antimalarial and antibacterial agents(2023)
Authors: Charlotte Courtens, Frits van Charante, Thibaut Quennesson, Martijn Risseeuw, Paul Cos, Guy Caljon, Tom Coenye, Serge Van Calenbergh
Pages: 1 - 14 - In-depth biological characterization of two black soldier fly anti- Pseudomonas peptides reveals LPS-binding and immunomodulating effects(2023)
Authors: Laurence Van Moll, Milan Wouters, Jeroen De Smet, Linda De Vooght, Peter Delputte, Mik Van Der Borght, Paul Cos
Pages: 1 - 15 - Development and validation of a multiplex electrochemiluminescence immunoassay to evaluate dry eye disease in rat tear fluids(2023)
Authors: Agnese Compagnone, Linda De Vooght, Paul Cos
Pages: 1 - 15 - In vitro persistence level reflects In vivo antibiotic survival of natural Pseudomonas aeruginosa isolates in a murine lung infection model(2023)
Authors: Laure Verstraete, Juliana Aizawa Porto de Abreu, Matthias Govaerts, Linda De Vooght, Rob Lavigne, Jan Michiels, Bram van den Bergh, Paul Cos
Pages: 1 - 17
Patents
1 - 5 of 5
- Compositions against candida infections (Inventor)
- Bis(acetamidophenyl) guanidinophenyethylphosphonates for use in the prevention and/or treatment of PAR-related diseases. (Inventor)
- Bis(acetamidophenyl) guanidinophenylethylphosphonates for use in the prevention and/or treatment of par-related diseases (Inventor)
- Compositions against candida infections (Inventor)
- Bis(acetamidophenyl) guanidinophenylethylphosphonates for use in the prevention and/or treatment of par-related diseases (Inventor)