Researcher
Niek Sanders
- Keywords:drug delivery, immunology, gene therapy, cancer therapy, cancer immunotherapy, vaccines, immunotherapy, mRNA vaccines
- Disciplines:Other veterinary sciences not elsewhere classified, Drug discovery and development not elsewhere classified, Biopharmaceuticals, Molecular medicine, Non-clinical studies, Vaccines, Animal health engineering, Laboratory animal medicine, Veterinary law and legislation, Veterinary herd health management, Agricultural, veterinary and food sciences not elsewhere classified, Veterinary medicine not elsewhere classified, Applied immunology, Cancer therapy, Gene and molecular therapy, Vaccinology, Veterinary immunology
Affiliations
- Department of Veterinary and Biosciences (Department)
Member
From1 Feb 2008 → Today - Department of Pharmaceutics (Department)
Member
From1 Oct 1997 → 30 Sep 2008
Projects
11 - 20 of 33
- Design and pre-clincial evaluation of self-replicating mRNA therapeutics that produce protein drugs under control of small, non-toxic moleculesFrom1 Nov 2020 → TodayFunding: FWO fellowships
- RNA synthetic biology for genetic engineering of the first vaccine for companion birds against the underestimated respiratory zoonotic pathogen Chlamydia psittaciFrom1 Nov 2020 → TodayFunding: FWO Strategic Basic Research Grant
- Cationic polymers with controlled charge separation for non-viral RNA deliveryFrom1 Oct 2020 → TodayFunding: BOF - projects
- Barriers and carriers for non-viral delivery of mRNA to induce transient protein expression in the retina: the hurdles of the inner limiting membrane and innate immunity versus the potential of mRNA self-amplification.From1 Nov 2019 → 31 Oct 2023Funding: FWO fellowships
- Barriers and carriers for non-viral delivery of mRNA to induce transient protein expression in the retina: the hurdles of the inner limiting membrane and innate immunity versus the potential of mRNA self-amplification.From1 Oct 2019 → 1 Nov 2019Funding: BOF - doctoral mandates
- A basic whole-body bioluminescent and fluorescent in vivo imaging system for small laboratory animalsFrom1 Jun 2018 → 31 May 2020Funding: BOF - Other initiatives
- An mRNA replicon based immunotherapeutic combinational treatment for triple negative breast cancerFrom1 Jan 2016 → 31 Dec 2019Funding: FWO Strategic Basic Research Grant
- A combinatorial cancer immunotherapy approach based on selfreplicating RNA From1 Jan 2016 → 31 Dec 2019Funding: FWO research project (including WEAVE projects)
- Messenger RNA transfected myeoloid-derived suppressor cells as cellular vehicles for tumor-targeted delivery of IL-12From1 Oct 2015 → 30 Sep 2019Funding: FWO fellowships
- The induction of intestinal immunity in a piglet modelFrom1 Jan 2015 → 31 Dec 2020Funding: BOF - Concerted Research Project from 1994
Publications
1 - 10 of 124
- Evaluation of a self-amplifying mRNA reporter vaccine in explant models of broiler chickens(2023)
Authors: Janne Snoeck, Koen Chiers, Ying Tam, Niek Sanders, An Garmyn
- Previous and current efforts to develop a mucosal vaccine against periodontal disease : are we close yet?(2023)
Authors: Victor Vaernewyck, Janne Snoeck, Eric Cox, Niek Sanders, Boaz Arzi, Maria Soltero-Rivera, Henriëtte Booij-Vrieling, Bert Devriendt
Pages: 191 - 193 - Lipid nanoparticle delivery alters the adjuvanticity of the TLR9 agonist CpG by innate immune activation in lymphoid tissue(2023)
Authors: Zifu Zhong, Yong Chen, Kim Deswarte, Heleen Lauwers, Emily De Lombaerde, Xiaole Cui, Simon Van Herck, Tingting Ye, Mark Gontsarik, Stefan Lienenklaus, et al.
- The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function(2023)
Authors: Tineke Vanderhaeghen, Steven Timmermans, Melanie Eggermont, Deepika Watts, Jolien Vandewalle, Charlotte Wallaeys, Louise Nuyttens, Joyca De Temmerman, Tino Hochepied, Sylviane Dewaele, et al.
- Evaluation of potential administration routes of self-amplifying mRNA in chickens using a reporter vaccine(2023)
Authors: Janne Snoeck, Kristof Haems, Ying Tam, Niek Sanders, An Garmyn
Number of pages: 1 - Novel polymers as promising non-viral carriers for self-amplifying mRNA-based applications(2023)
Authors: Lisa Opsomer, Somdeb Jana, Ine Mertens, Richard Hoogenboom, Niek Sanders
Number of pages: 1 - Xenogeneic equine stem cells activate anti-tumor adaptive immunity in a 4T1-based intraductal mouse model for triple-negative breast cancer : proof-of-principle(2023)
Authors: Jonas Steenbrugge, Glenn Pauwelyn, Kristel Demeyere, Nausikaa Devriendt, Hilde De Rooster, Niek Sanders, Jan H. Spaas, Evelyne Meyer, Sina Naserian
- Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics(2022)
Authors: Marie Pauwels, Junhua Xie, Adam Ceroi, Sriram Balusu, Jonas Castelein, Elien Van Wonterghem, Griet Van Imschoot, Andrew Ward, Trevelyan R. Menheniott, Oskar Gustafsson, et al.
- One cisplatin dose provides durable stimulation of anti-tumor immunity and alleviates anti-PD-1 resistance in an intraductal model for triple-negative breast cancer(2022)
Authors: Jonas Steenbrugge, Julie Bellemans, Niels Vander Elst, Josephine De Vliegher, Timothy Perera, Ward De Spiegelaere, Niek Sanders
- Regulatory guidelines and preclinical tools to study the biodistribution of RNA therapeutics(2022)
Authors: Pieter Vervaeke, S.E. Borgos, Niek Sanders, F. Combes