Researcher
Niek Sanders
- Keywords:drug delivery, immunology, gene therapy, cancer therapy, cancer immunotherapy, vaccines, immunotherapy, mRNA vaccines
- Disciplines:Other veterinary sciences not elsewhere classified, Drug discovery and development not elsewhere classified, Biopharmaceuticals, Molecular medicine, Non-clinical studies, Vaccines, Animal health engineering, Laboratory animal medicine, Veterinary law and legislation, Veterinary herd health management, Agricultural, veterinary and food sciences not elsewhere classified, Veterinary medicine not elsewhere classified, Applied immunology, Cancer therapy, Gene and molecular therapy, Vaccinology, Veterinary immunology
Affiliations
- Department of Veterinary and Biosciences (Department)
Member
From1 Feb 2008 → Today - Department of Pharmaceutics (Department)
Member
From1 Oct 1997 → 30 Sep 2008
Projects
1 - 10 of 33
- Efficacy and immunological aspects of self-amplifying (sa) RNA vaccines encoding avian influenza antigensFrom15 Jun 2024 → TodayFunding: BOF - doctoral mandates
- Replacement of confocal fluorescence microscope for visualisation of biological processes in humans and animalsFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Novel cationic polymers for RNA vaccinationFrom15 Dec 2022 → TodayFunding: IOF - technology concept exploration
- Introducing mRNA vaccination in chicken: first steps towards a commercial mRNA vaccine against a leading viral infection in chickenFrom1 Nov 2022 → TodayFunding: IOF - technology validation in lab
- A self-amplifying mRNA-based combinatorial immunotherapy for treating colorectal cancerFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Development of a buccal self-amplifying mRNA vaccine for periodontal disease prophylaxis in dogs.From1 Nov 2021 → 30 Jun 2023Funding: FWO Strategic Basic Research Grant
- Biofabrication of vasculature for organ engineering and bypass graftingFrom1 Nov 2021 → TodayFunding: FWO fellowships
- BioGelator for local immunotherapyFrom15 Jul 2021 → TodayFunding: IOF - technology validation in lab
- High throughput automatization of cell and organoid based assays for cross-health valorization -Acronym: ACOBAFrom1 May 2021 → 30 Apr 2023Funding: IOF - technology validation in lab
- Design of a Chlamydia vaccineFrom1 Nov 2020 → TodayFunding: BOF - doctoral mandates
Publications
31 - 40 of 124
- The opposing effect of type I IFN on the T cell response by non-modified mRNA-lipoplex vaccines Is determined by the route of administration(2020)
Authors: Lien Van Hoecke, Marlies Ballegeer, Niek Sanders, Stefaan De Koker
Pages: 373 - 381 - Expression kinetics and innate immune response after electroporation and LNP-mediated delivery of a self-amplifying mRNA in the skin(2019)
Authors: Hanne Huysmans, Joyca De Temmerman, Barbara L Mui, Ying K Tam, Séan Mc Cafferty, Arlieke Gitsels, Niek Sanders
Pages: 867 - 878 - Comparative profiling of metastatic 4T1- vs. non-metastatic Py230-based mammary tumors in an intraductal model for triple-negative breast cancer(2019)
Authors: Jonas Steenbrugge, Niels Vander Elst, Kristel Demeyere, Olivier De Wever, Niek Sanders, Wim Van Den Broeck, Luc Dirix, Steven Van Laere, Evelyne Meyer
- Improving the repeatability and efficacy of intradermal electroporated self-replicating mRNA(2019)
Authors: Hanne Huysmans, Joyca De Temmerman, Séan Mc Cafferty, Francis Combes, Niek Sanders
Pages: 388 - 395 - Chlamydial infection from outside to inside(2019)
Authors: Arlieke Gitsels, Niek Sanders, Daisy Vanrompay
- Immunogenicity and protection efficacy of a naked self-replicating mRNA-based Zika virus vaccine(2019)
Authors: Zifu Zhong, João Paulo Portela Catani, Séan Mc Cafferty, Liesbeth Couck, Wim Van Den Broeck, Nina Gorlé, Roosmarijn Vandenbroucke, Bert Devriendt, Sebastian Ulbert, Lieselotte Cnops, et al.
- Mononuclear but not polymorphonuclear phagocyte depletion increases circulation times and improves mammary tumor-homing efficiency of donor bone marrow-derived monocytes(2019)
Authors: Francis Combes, Alexandros Marios Sofias, Séan Mc Cafferty, Hanne Huysmans, Joyca De Temmerman, Sjoerd Hak, Evelyne Meyer, Niek Sanders
- Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists(2019)
Authors: Jana De Vrieze, Benoit Louage, Kim Deswarte, Zifu Zhong, Ruben De Coen, Simon Van Herck, Lutz Nuhn, Camilla Kaas Frich, Alexander N Zelikin, Stefan Lienenklaus, et al.
Pages: 15390 - 15395 - mRNA therapeutics deliver a hopeful message(2018)
Authors: Séan Mc Cafferty, Francis Combes, Hanne Huysmans, Joyca De Temmerman, Arlieke Gitsels, Niek Sanders
Pages: 16 - 39 - Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer(2018)
Authors: Jonas Steenbrugge, Koen Breyne, Kristel Demeyere, Olivier De Wever, Niek Sanders, Wim Van Den Broeck, Cecile Colpaert, Peter Vermeulen, Steven Van Laere, Evelyne Meyer