Researcher
Niek Sanders
- Keywords:drug delivery, immunology, gene therapy, cancer therapy, cancer immunotherapy, vaccines, immunotherapy, mRNA vaccines
- Disciplines:Other veterinary sciences not elsewhere classified, Drug discovery and development not elsewhere classified, Biopharmaceuticals, Molecular medicine, Non-clinical studies, Vaccines, Animal health engineering, Laboratory animal medicine, Veterinary law and legislation, Veterinary herd health management, Agricultural, veterinary and food sciences not elsewhere classified, Veterinary medicine not elsewhere classified, Applied immunology , Cancer therapy , Gene and molecular therapy, Vaccinology, Veterinary immunology
Affiliations
- Department of Veterinary and Biosciences (Department)
Member
From1 Feb 2008 → Today - Department of Pharmaceutics (Department)
Member
From1 Oct 1997 → 30 Sep 2008
Projects
1 - 10 of 29
- A self-amplifying mRNA-based combinatorial immunotherapy for treating colorectal cancerFrom1 Jan 2022 → TodayFunding: FWO research project
- Biofabrication of vasculature for organ engineering and bypass graftingFrom1 Nov 2021 → TodayFunding: FWO fellowships
- Development of a buccal self-amplifying mRNA vaccine for periodontal disease prophylaxis in dogs.From1 Nov 2021 → TodayFunding: FWO Strategic Basic Research Grant
- BioGelator for local immunotherapyFrom15 Jul 2021 → TodayFunding: IOF - technology validation in lab
- High throughput automatization of cell and organoid based assays for cross-health valorization -Acronym: ACOBAFrom1 May 2021 → TodayFunding: IOF - technology validation in lab
- RNA synthetic biology for genetic engineering of the first vaccine for companion birds against the underestimated respiratory zoonotic pathogen Chlamydia psittaciFrom1 Nov 2020 → TodayFunding: FWO Strategic Basic Research Grant
- Design and pre-clincial evaluation of self-replicating mRNA therapeutics that produce protein drugs under control of small, non-toxic moleculesFrom1 Nov 2020 → TodayFunding: FWO fellowships
- Design of a Chlamydia vaccineFrom1 Nov 2020 → TodayFunding: BOF - doctoral mandates
- Cationic polymers with controlled charge separation for non-viral RNA deliveryFrom1 Oct 2020 → TodayFunding: BOF - projects
- Barriers and carriers for non-viral delivery of mRNA to induce transient protein expression in the retina: the hurdles of the inner limiting membrane and innate immunity versus the potential of mRNA self-amplification.From1 Nov 2019 → TodayFunding: FWO fellowships
Publications
1 - 10 of 110
- Regulatory guidelines and preclinical tools to study the biodistribution of RNA therapeutics(2022)
Authors: Pieter Vervaeke, S.E. Borgos, Niek Sanders, F. Combes
Number of pages: 1 - Squaric ester-based, pH-degradable nanogels : modular nanocarriers for safe, systemic administration of toll-like receptor 7/8 agonistic immune modulators(2021)
Authors: Anne Huppertsberg, Leonard Kaps, Zifu Zhong, Sascha Schmitt, Judith Stickdorn, Kim Deswarte, Francis Combes, Christian Czysch, Jana De Vrieze, Sabah Kasmi, et al.
Pages: 9872 - 9883 - Mucosal vaccination against periodontal disease : current status and opportunities(2021)
Authors: Victor Vaernewyck, Boaz Arzi, Niek Sanders, Eric Cox, Bert Devriendt
Number of pages: 1 - Low-dose single-shot COVID-19 mRNA vaccines lie ahead(2021)
Authors: Niek Sanders
Pages: 1944 - 1945 - Corticosteroids and cellulose purification improve, respectively, the in vivo translation and vaccination efficacy of sa-mRNAs(2021)
Authors: Zifu Zhong, Séan Mc Cafferty, Lisa Opsomer, Haixiu Wang, Hanne Huysmans, Joyca De Temmerman, Stefan Lienenklaus, João Portela Catani, Francis Combes, Niek Sanders
Pages: 1370 - 1381 - Sterilizing immunity against SARSU+2010CoVU+20102 infection in mice by a singleU+2010shot and lipid amphiphile imidazoquinoline TLR7/8 agonistU+2010adjuvanted recombinant spike protein vaccine**(2021)
Authors: Sonia Jangra, Jana De Vrieze, Angela Choi, Raveen Rathnasinghe, Gabriel Laghlali, Annemiek Uvyn, Simon Van Herck, Lutz Nuhn, Kim Deswarte, Zifu Zhong, et al.
Pages: 9467 - 9473 - Unexpected effects of a selective and potent c-MET inhibitor in an immunocompetent intraductal model for triple-negative breast cancer(2021)
Authors: Jonas Steenbrugge, Niels Vander Elst, Kristel Demeyere, Olivier De Wever, Niek Sanders, Wim Van Den Broeck, Annegret Van der Aa, Eric Ciamporcero, Timothy Perera, Evelyne Meyer
Number of pages: 1 - Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics : getting the message across(2021)
Authors: An-Katrien Minnaert, Helena Vanluchene, Rein Verbeke, Sabine Lentacker, Stefaan De Smedt, Koen Raemdonck, Niek Sanders, Katrien Remaut
Number of pages: 1 - OMO-1 reduces progression and enhances cisplatin efficacy in a 4T1-based non-c-MET addicted intraductal mouse model for triple-negative breast cancer(2021)
Authors: Jonas Steenbrugge, Niels Vander Elst, Kristel Demeyere, Olivier De Wever, Niek Sanders, Wim Van Den Broeck, Eric Ciamporcero, Timothy Perera, Evelyne Meyer
Number of pages: 1 - Lipid-polyglutamate nanoparticle vaccine platform(2021)
Authors: Dorien Van Lysebetten, Alessio Malfanti, Kim Deswarte, Kaloian Koynov, Bianka Golba, Tingting Ye, Zifu Zhong, Sabah Kasmi, Alexander Lamoot, Yong Chen, et al.
Pages: 6011 - 6022