Researcher
Niek Sanders
- Keywords:drug delivery, immunology, gene therapy, cancer therapy, cancer immunotherapy, vaccines, immunotherapy
- Disciplines:Other veterinary sciences not elsewhere classified, Drug discovery and development not elsewhere classified, Biopharmaceuticals, Molecular medicine, Non-clinical studies, Vaccines, Animal health engineering, Laboratory animal medicine, Veterinary law and legislation, Veterinary herd health management, Agricultural, veterinary and food sciences not elsewhere classified, Veterinary medicine not elsewhere classified, Applied immunology , Cancer therapy , Gene and molecular therapy, Vaccinology, Veterinary immunology
Affiliations
- Department of Nutrition, Genetics and Ethology (Department)
Member
From1 Feb 2008 → Today - Department of Pharmaceutics (Department)
Member
From1 Oct 2002 → 30 Sep 2008
Projects
1 - 10 of 24 results
- Design and pre-clincial evaluation of self-replicating mRNA therapeutics that produce protein drugs under control of small, non-toxic moleculesFrom1 Nov 2020 → TodayFunding: FWO fellowships
- RNA synthetic biology for genetic engineering of the first vaccine for companion birds against the underestimated respiratory zoonotic pathogen Chlamydia psittaciFrom1 Nov 2020 → TodayFunding: FWO Strategic Basic Research Grant
- Design of a Chlamydia vaccineFrom1 Nov 2020 → TodayFunding: BOF - doctoral mandates
- Cationic polymers with controlled charge separation for non-viral RNA deliveryFrom1 Oct 2020 → TodayFunding: BOF - projects
- Barriers and carriers for non-viral delivery of mRNA to induce transient protein expression in the retina: the hurdles of the inner limiting membrane and innate immunity versus the potential of mRNA self-amplification.From1 Nov 2019 → TodayFunding: FWO fellowships
- Barriers and carriers for non-viral delivery of mRNA to induce transient protein expression in the retina: the hurdles of the inner limiting membrane and innate immunity versus the potential of mRNA self-amplification.From1 Oct 2019 → 1 Nov 2019Funding: BOF - doctoral mandates
- A basic whole-body bioluminescent and fluorescent in vivo imaging system for small laboratory animalsFrom1 Jun 2018 → 31 May 2020Funding: BOF - Other initiatives
- A combinatorial cancer immunotherapy approach based on selfreplicating RNA From1 Jan 2016 → 31 Dec 2019Funding: FWO research project
- An mRNA replicon based immunotherapeutic combinational treatment for triple negative breast cancerFrom1 Jan 2016 → 31 Dec 2019Funding: FWO Strategic Basic Research Grant
- Messenger RNA transfected myeoloid-derived suppressor cells as cellular vehicles for tumor-targeted delivery of IL-12From1 Oct 2015 → 30 Sep 2019Funding: FWO fellowships
Publications
1 - 10 of 90 results
- Imidazoquinoline-conjugated degradable coacervate conjugate for local cancer immunotherapy(2020)
Authors: Hui Li, Simon Van Herck, Yongjun Liu, Yanyun Hao, Xiaochu Ding, Lutz Nuhn, Zifu Zhong, Francis Combes, Niek Sanders, Stefan Lienenklaus, et al.
Pages: 4993 - 5000 - Chlamydia : what is on the outside does matter(2020)
Authors: Arlieke Gitsels, Sarah Van Lent, Niek Sanders, Daisy Vanrompay
Pages: 100 - 119 - The opposing effect of type I IFN on the T cell response by non-modified mRNA-lipoplex vaccines Is determined by the route of administration(2020)
Authors: Lien Van Hoecke, Kenny Roose, Marlies Ballegeer, Zifu Zhong, Niek Sanders, Stefaan De Koker, Xavier Saelens, Sandra Van Lint
Pages: 373 - 381 - Chlamydial infection from outside to inside(2019)
Authors: Arlieke Gitsels, Niek Sanders, Daisy Vanrompay
Number of pages: 1 - Immunogenicity and protection efficacy of a naked self-replicating mRNA-based Zika virus vaccine(2019)
Authors: Zifu Zhong, João Paulo Portela Catani, Séan Mc Cafferty, Liesbeth Couck, Wim Van Den Broeck, Nina Gorlé, Roosmarijn Vandenbroucke, Bert Devriendt, Sebastian Ulbert, Lieselotte Cnops, et al.
Number of pages: 1 - Nanoparticle-conjugate TLR7/8 agonist localized immunotherapy provokes safe antitumoral responses(2018)
Authors: Lutz Nuhn, Stefaan De Koker, Sandra Van Lint, Zifu Zhong, João Portela Catani, Francis Combes, Kim Deswarte, Yupeng Li, Bart Lambrecht, Stefan Lienenklaus, et al.
Number of pages: 1 - Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer(2018)
Authors: Jonas Steenbrugge, Koen Breyne, Kristel Demeyere, Olivier De Wever, Niek Sanders, Wim Van Den Broeck, Cecile Colpaert, Peter Vermeulen, Steven Van Laere, Evelyne Meyer
Number of pages: 1 - mRNA therapeutics deliver a hopeful message(2018)
Authors: Zifu Zhong, Séan Mc Cafferty, Francis Combes, Hanne Huysmans, Joyca De Temmerman, Arlieke Gitsels, Daisy Vanrompay, João Portela Catani, Niek Sanders
Pages: 16 - 39 - Off-target and tumor-specific accumulation of monocytes, macrophages and myeloid-derived suppressor cells after systemic injection(2018)
Authors: Francis Combes, Séan Mc Cafferty, Evelyne Meyer, Niek Sanders
Pages: 848 - 856 - Comparison of the expression kinetics and immunostimulatory activity of replicating mRNA, nonreplicating mRNA, and pDNA after intradermal electroporation in pigs(2018)
Authors: Bregje Leyman, Hanne Huysmans, Séan Mc Cafferty, Francis Combes, Eric Cox, Bert Devriendt, Niek Sanders
Pages: 377 - 384