Researcher
Max Mazzone
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Cancer biology
- Disciplines (KU Leuven):Morphological sciences, Oncology
- See also: Mazzone Max (Flanders Institute for Biotechnology)
Affiliations
- Laboratory of Tumor Inflammation and Angiogenesis (VIB-KU Leuven) (Division)
Responsible
From1 Jan 2012 → Today - Mazzone Lab (Research group)
Responsible
From1 Jan 2017 → Today - Laboratory of Tumor Inflammation and Angiogenesis (VIB-KU Leuven) (Division)
Member
From1 Jan 2012 → 30 Sep 2022
Projects
31 - 40 of 63
- A metabolic gene survey pinpoints fucosylation as a key pathway underlying the suppressive function of Regulatory T cells in cancer.From21 Sep 2017 → 16 May 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancerFrom4 Sep 2017 → 26 Jan 2023Funding: Foundations, funds and other with scientific goal
- A comparative clinical study of a stool-based versus a blood-based screening test for earlydetection of CRCFrom1 Apr 2017 → 30 Sep 2018Funding: Own budget, for example: patrimony, inscription fees, gifts
- Role of the PP2A regulatory subunit B55α in tumor stromal cells and its validation as a potential target to inhibit cancer progressionFrom1 Jan 2017 → 31 Dec 2018Funding: Private funding of national origin - undefined
- Metabolism following function or function following metabolism: a study of AMPK in tumor-associated macrophagesFrom1 Jan 2017 → 31 Dec 2020Funding: FWO research project (including WEAVE projects)
- Exploring the role of TRAIL pathway in the tumor stroma: implications for cancer progression and drug resistanceFrom1 Jan 2017 → 31 Dec 2020Funding: FWO research project (including WEAVE projects)
- AMPK: a master switch integrating metamoblism and immune effector functions in tumor-associated macrophagesFrom1 Oct 2016 → 30 Sep 2020Funding: FWO fellowships
- Exploring how TAMs hijack the TRAIL system to fuel tumor progression and drug resistanceFrom1 Oct 2016 → 22 May 2023Funding: FWO fellowships
- Unraveling the role of the PP2A regulatory subunit B55alpha in tumor-infiltrating immune cellsFrom1 Jul 2016 → 11 Feb 2022Funding: FWO Strategic Basic Research Grant, Nonprofit institution or equivalents
- Development of a technology platform for next-generation cytometryFrom1 Jul 2016 → 30 Jun 2020Funding: FWO Large scale research infrastructure
Publications
1 - 10 of 182
- A Metabolic Gene Survey Pinpoints Fucosylation as a Key Pathway Underlying the Suppressive Function of Regulatory T Cells in Cancer(2023)
Authors: Ria Pinioti, Susan Schlenner, Bernard Thienpont, Abhishek Garg, Max Mazzone
Pages: 1611 - 1629 - Candida albicans stimulates formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection(2023)
Authors: Max Mazzone
- A metabolic gene survey pinpoints fucosylation as a key pathway underlying the suppressive function of Regulatory T cells in cancer.(2023)
Authors: Ria Pinioti, Max Mazzone, Mario di Matteo
Number of pages: 19 - Breast tumors interfere with endothelial TRAIL at the premetastatic niche to promote cancer cell seeding(2023)
Authors: Maxim De Schepper, Tatjana Geukens, Stefaan Soenen, Christine Desmedt, Colinda Scheele, Anna Sablina, Max Mazzone
- A collaborative synthetase(2023)
Authors: Max Mazzone
Pages: 255 - 256 - PHD2 Constrains Antitumor CD8+T-cell Activity(2023)
Authors: Max Mazzone
Pages: 339 - 350 - A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling(2023)
Authors: Ginevra Doglioni, Alex Cuadros, Xiaozheng Liu, dorien Broekaert, Sofie Demeyer, Xander Spotbeen, Margherita Demicco, François Richard, Tatjana Geukens, Maxim De Schepper, et al.
Pages: 344 - + - Mitochondria metabolism sets the species-specific tempo of neuronal development(2023)
Authors: Ryohei Iwata, Pierre Casimir, Emir Erkol, Sofie Beckers, Anke Vandekeere, Pieter Vermeersch, Sebastien Carpentier, Kristofer Davie, Max Mazzone, Stein Aerts, et al.
Pages: 553 - + - Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer(2023)
Authors: Federica Cappellesso, Max Mazzone, Baki Topal
Number of pages: 37 - Stroma-derived miR-214 coordinates tumor dissemination.(2023)
Authors: Max Mazzone
Pages: 20
Patents
1 - 10 of 10
- Cd8+ t-cells lacking plexins and their application in cancer treatment (Inventor)
- Cancer treatment by targeting plexins in the immune compartment (Inventor)
- Biomarker for anti-tumor therapy (Inventor)
- Inhibition of slc4a4 in the treatment of cancer (Inventor)
- Combination of p2y6 inhibitors and immune checkpoint inhibitors (Inventor)
- Means and methods to treat inflammatory diseases (Inventor)
- Glutamine dehydrogenase inhibitors for use in muscle regeneration (Inventor)
- Cd8+ t-cells lacking plexins and their application in cancer treatment (Inventor)
- Podoplanin positive macrophages (Inventor)
- Cancer treatment by targeting plexins in the immune compartment (Inventor)