Researcher
Max Mazzone
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Cancer biology
- Disciplines (KU Leuven):Morphological sciences, Oncology
- See also: Mazzone Max (Flanders Institute for Biotechnology)
Affiliations
- Laboratory of Tumor Inflammation and Angiogenesis (VIB-KU Leuven) (Division)
Responsible
From1 Jan 2012 → Today - Mazzone Lab (Research group)
Responsible
From1 Jan 2017 → Today - Laboratory of Tumor Inflammation and Angiogenesis (VIB-KU Leuven) (Division)
Member
From1 Jan 2012 → 30 Sep 2022
Projects
21 - 30 of 62
- Exploring mechanisms of immunotherapy resistance in pancreatic cancerFrom3 May 2019 → 16 Feb 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- Integrated IMMUnoprofiling of large adaptive CANcer patients cohortsFrom1 Mar 2019 → TodayFunding: H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and wellbeing, H2020 - European Institute of Innovation and Technology
- Exploring the role of PlexinA4 in cytotoxic T cells: insights for antitumor immune response & cancer immunotherapyFrom1 Feb 2019 → 31 Oct 2023Funding: FWO fellowships, Foundations, funds and other with scientific goal
- Metabolic editing of the tumor microenvironment as a novel strategy to abate immunosuppressionFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Exploring the role of PlexinA4 in cytotoxic T cells: insights for antitumor immune response & cancer immunotherapyFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Harnessing tumor metabolism to overcome immunosupressionFrom1 Jul 2018 → 30 Jun 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Mass cytometry by time-of-flight: next-generation flow cytometry for multiplexed single cell analysisFrom1 May 2018 → 30 Apr 2022Funding: FWO Medium Size Research Infrastructure
- Harnessing the intrinsic metabolism of CD8+ T cells to improve their anti-tumor immune responseFrom5 Feb 2018 → 31 Oct 2023Funding: FWO Strategic Basic Research Grant, Foundations, funds and other with scientific goal
- MATATUM: Validation and druggability development of macrophage-specific targets in the tumor microenvironment.From1 Jan 2018 → 31 Dec 2021Funding: FWO Strategic Basic Research (SBO)
- A metabolic gene survey pinpoints fucosylation as a key pathway underlying the suppressive function of Regulatory T cells in cancer.From21 Sep 2017 → 16 May 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 179
- A Metabolic Gene Survey Pinpoints Fucosylation as a Key Pathway Underlying the Suppressive Function of Regulatory T Cells in Cancer(2023)
Authors: Ria Pinioti, Susan Schlenner, Bernard Thienpont, Abhishek Garg, Max Mazzone
Pages: 1611 - 1629 - Candida albicans stimulates formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection(2023)
Authors: Max Mazzone
- A metabolic gene survey pinpoints fucosylation as a key pathway underlying the suppressive function of Regulatory T cells in cancer.(2023)
Authors: Ria Pinioti, Max Mazzone, Mario di Matteo
Number of pages: 19 - Breast tumors interfere with endothelial TRAIL at the premetastatic niche to promote cancer cell seeding(2023)
Authors: Maxim De Schepper, Tatjana Geukens, Stefaan Soenen, Christine Desmedt, Colinda Scheele, Anna Sablina, Max Mazzone
- A collaborative synthetase(2023)
Authors: Max Mazzone
Pages: 255 - 256 - PHD2 Constrains Antitumor CD8+T-cell Activity(2023)
Authors: Max Mazzone
Pages: 339 - 350 - A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling(2023)
Authors: Ginevra Doglioni, Alex Cuadros, Xiaozheng Liu, dorien Broekaert, Sofie Demeyer, Xander Spotbeen, Margherita Demicco, François Richard, Tatjana Geukens, Maxim De Schepper, et al.
Pages: 344 - + - Mitochondria metabolism sets the species-specific tempo of neuronal development(2023)
Authors: Ryohei Iwata, Pierre Casimir, Emir Erkol, Sofie Beckers, Anke Vandekeere, Pieter Vermeersch, Sebastien Carpentier, Kristofer Davie, Max Mazzone, Stein Aerts, et al.
Pages: 553 - + - Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer(2023)
Authors: Federica Cappellesso, Max Mazzone, Baki Topal
Number of pages: 37 - Stroma-derived miR-214 coordinates tumor dissemination.(2023)
Authors: Max Mazzone
Pages: 20
Patents
1 - 10 of 10
- Cd8+ t-cells lacking plexins and their application in cancer treatment (Inventor)
- Cancer treatment by targeting plexins in the immune compartment (Inventor)
- Biomarker for anti-tumor therapy (Inventor)
- Combination of p2y6 inhibitors and immune checkpoint inhibitors (Inventor)
- Inhibition of slc4a4 in the treatment of cancer (Inventor)
- Means and methods to treat inflammatory diseases (Inventor)
- Glutamine dehydrogenase inhibitors for use in muscle regeneration (Inventor)
- Cd8+ t-cells lacking plexins and their application in cancer treatment (Inventor)
- Podoplanin positive macrophages (Inventor)
- Cancer treatment by targeting plexins in the immune compartment (Inventor)