Researcher
Matthias D'hooghe
- Disciplines:Organic chemical synthesis, Medicinal chemistry
Affiliations
- Department of Green Chemistry and Technology (Department)
Member
From1 Jan 2018 → Today - Department of Sustainable Organic Chemistry and Technology (Department)
Member
From1 Sep 2001 → 31 Dec 2017
Projects
1 - 10 of 31
- Development of hybrid molecules targeting glucocorticoid and peroxisome proliferator-activated receptor-based heterodimers to combat inflammationFrom1 Nov 2023 → TodayFunding: BOF - doctoral mandates
- Development of steroid-based GR-PPARα conjugates for the treatment of chronic inflammatory diseasesFrom1 Oct 2023 → TodayFunding: BOF - projects
- Out of limbo: a toolbox to eliminate ambiguity around HDAC6, offering a novel therapeutic opportunity against multiple myeloma.From1 Apr 2023 → 30 Apr 2023Funding: BOF - doctoral mandates
- Purchase of LC-MS equipment for the analysis of organic compounds, reaction mixtures and natural extractsFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Curcumin-derived functionalized thiazepanes to selectively target colon cancer cellsFrom1 Nov 2022 → TodayFunding: FWO Strategic Basic Research Grant
- Validation of a small molecule system for a safer treatment of chronic inflammationFrom15 Jul 2022 → TodayFunding: IOF - technology validation in lab
- Design and development of carbapenem- and cephalosporin-based monocyclic beta-lactam derivatives to address antibiotic-insensitive penicillin-binding proteinsFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Curcumin-derived functionalized thiazepanes to selectively target colon cancer cellFrom1 Oct 2021 → 31 Oct 2022Funding: BOF - doctoral mandates
- Purchase of GC-MS equipment for the analysis of volatile organic compounds.From1 Dec 2020 → 30 Nov 2022Funding: BOF - scientific equipment program
- From thiazepane curcuminoid hit structures to new anticancer lead compoundsFrom1 Oct 2020 → TodayFunding: BOF - projects
Publications
141 - 150 of 163
- Synthesis and antiplasmodial evaluation of novel (4-aminobutyloxy)quinolines
Authors: Stephanie Vandekerckhove, Christian Müller, Dieter Vogt, Carmen Lategan, Peter J Smith, Kelly Chibale, Norbert De Kimpe, Matthias D'hooghe
Pages: 318 - 322 - Stereoselective synthesis of chiral 4-(1-chloroalkyl)-U+03B2-lactams starting from amino acids and their transformation into functionalized chiral azetidines and pyrrolidines
Authors: Stijn Dekeukeleire, Matthias D'hooghe, Karl Törnroos, Norbert De Kimpe
Pages: 5934 - 5940 - Synthesis of stereodefined piperidines from aziridines and their transformation into conformationally constrained amino acids, amino alcohols and 2,7-diazabicyclo[3.3.1]nonanes
Authors: Karel Vervisch, Matthias D'hooghe, Karl Törnroos, Norbert De Kimpe
Pages: 7734 - 7744 - Straightforward synthesis of 1-alkyl-2-(trifluoromethyl)aziridines starting from 1,1,1-trifluoroacetone
Authors: Sara Kenis, Matthias D'hooghe, Guido Verniest, Vinh Duc Nguyen, Anh Dang Thi Tuyet, Tuyen Van Nguyen, Norbert De Kimpe
Pages: 7217 - 7223 - Synthesis and reactivity of 3-haloazetidines and 3-sulfonyloxyazetidines: a review
Authors: Willem Van Brabandt, Matthias D'hooghe, Berten Van Driessche, Norbert De Kimpe, Tamás Patonay
Pages: 827 - 851 - Synthesis of 2-aminomethyl-4-phenyl-1-azabicyclo[2.2.1]heptanes via LiAlH4-induced reductive cyclization of 2-(4-chloro-2-cyano-2-phenylbutyl) aziridines and evaluation of their antimalarial activity
Authors: Matthias D'hooghe, Karel Vervisch, Karl W Törnroos, Tom Verhaeghe, Carmen Lategan, Peter J Smith, Kelly Chibale, Norbert De Kimpe
Pages: 1507 - 1510 - Synthesis and cytotoxic evaluation of novel dihydrobenzo[h]cinnoline-5,6-diones
Authors: Tuyet Anh Dang Thi, Lena Decuyper, Hoang Thi Phuong, Doan Vu Ngoc, Ha Thanh Nguyen, Tra Thanh Nguyen, Thanh Do Huy, Hung Huy Nguyen, Matthias D'hooghe, Tuyen Van Nguyen
Pages: 5855 - 5858 - Discovery of anxiolytic 2-ferrocenyl-1,3-thiazolidin-4-ones exerting GABA(A) receptor interaction via the benzodiazepine-binding site
Authors: Anka Pejović, Marija S Denic, Dragana Stevanovic, Ivan Darnljanovic, Mirjana Vukicevic, Kalina Kostova, Maya Tavlinova-Kirilova, Pavle Randjelovic, Nikola M Stojanovic, Goran A Bogdanovic, et al.
Pages: 57 - 73 - Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid-AZT conjugates
Authors: Hang Dao Thi, Nguyen Thi Kim Tuyet, Chinh Pham The, Ha Thanh Nguyen, Cham Ba Thi, Tien Doan Duy, Matthias D'hooghe, Tuyen Van Nguyen
Pages: 5190 - 5194 - Synthesis and cytotoxic evaluation of novel amide-triazole-linked triterpenoid-AZT conjugates
Authors: Hang Dao Thi, Nguyen Thi Kim Tuyet, Chinh Pham The, Ha Thanh Nguyen, Cham Ba Thi, Hoang Thi Phuong, Luu Van Boi, Tuyen Van Nguyen, Matthias D'hooghe
Pages: 218 - 224
Patents
1 - 2 of 2
- Selective HDAC6 inhibitors and uses thereof (Inventor)
- HDAC6 Inhibitors and uses thereof (Inventor)