Researcher
Matthias D'hooghe
- Disciplines:Organic chemical synthesis, Medicinal chemistry
Affiliations
- Department of Green Chemistry and Technology (Department)
Member
From1 Jan 2018 → Today - Department of Sustainable Organic Chemistry and Technology (Department)
Member
From1 Sep 2001 → 31 Dec 2017
Projects
1 - 10 of 31
- Development of hybrid molecules targeting glucocorticoid and peroxisome proliferator-activated receptor-based heterodimers to combat inflammationFrom1 Nov 2023 → TodayFunding: BOF - doctoral mandates
- Development of steroid-based GR-PPARα conjugates for the treatment of chronic inflammatory diseasesFrom1 Oct 2023 → TodayFunding: BOF - projects
- Out of limbo: a toolbox to eliminate ambiguity around HDAC6, offering a novel therapeutic opportunity against multiple myeloma.From1 Apr 2023 → 30 Apr 2023Funding: BOF - doctoral mandates
- Purchase of LC-MS equipment for the analysis of organic compounds, reaction mixtures and natural extractsFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Curcumin-derived functionalized thiazepanes to selectively target colon cancer cellsFrom1 Nov 2022 → TodayFunding: FWO Strategic Basic Research Grant
- Validation of a small molecule system for a safer treatment of chronic inflammationFrom15 Jul 2022 → TodayFunding: IOF - technology validation in lab
- Design and development of carbapenem- and cephalosporin-based monocyclic beta-lactam derivatives to address antibiotic-insensitive penicillin-binding proteinsFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Curcumin-derived functionalized thiazepanes to selectively target colon cancer cellFrom1 Oct 2021 → 31 Oct 2022Funding: BOF - doctoral mandates
- Purchase of GC-MS equipment for the analysis of volatile organic compounds.From1 Dec 2020 → 30 Nov 2022Funding: BOF - scientific equipment program
- From thiazepane curcuminoid hit structures to new anticancer lead compoundsFrom1 Oct 2020 → TodayFunding: BOF - projects
Publications
131 - 140 of 163
- Antibacterial and β-lactamase inhibitory activity of monocyclic β-lactams
Authors: Lena Decuyper, Marko Jukic, Izidor Sosic, Ales Zula, Matthias D'hooghe, Stanislav Gobec
Pages: 426 - 503 - Theoretical insight into the regioselective ring-expansions of bicyclic aziridinium ions
Authors: Esma B Boydas, Gamze Tanriver, Matthias D'hooghe, Hyun-Joon Ha, Saron Catak
Pages: 796 - 806 - Use of 3-hydroxy-4-(trifluoromethyl)azetidin-2-ones as building blocks for the preparation of trifluoromethyl-containing aminopropanes, 1,3-oxazinan-2-ones, aziridines, and 1,4-dioxan-2-ones
Authors: Hang Dao Thi, Giang Le Nhat Thuy, Saron Catak, Tuyen Van Nguyen, Matthias D'hooghe
Pages: 1439 - 1456 - Synthesis and reactivity of 4-(trifluoromethyl)azetidin-2-ones
Authors: Hang Dao Thi, Tuyen Van Nguyen, Matthias D'hooghe
Pages: 687 - 700 - A de novo synthetic method to the access of N-substituted benzazepines
Authors: Lamiaa Ouchakour, Melinda Nonn, Matthias D'hooghe, Lorand Kiss
- Synthesis of novel 4-ferrocenyl-1,2,3,4-tetrahydroquinolines and 4-ferrocenylquinolines via α-ferrocenyl carbenium ions as key intermediates
Authors: Aleksandra Minic, Dragana Stevanovic, Mirjana Vukicevic, Goran A Bogdanovic, Matthias D'hooghe, Niko S Radulovic, Rastko D Vukicevic
Pages: 6268 - 6274 - Exploration of aziridine- and U+03B2-lactam-based hybrids as both bioactive substances and synthetic intermediates in medicinal chemistry
Authors: Stephanie Vandekerckhove, Matthias D'hooghe
Pages: 3643 - 3647 - Synthesis and applications of benzohydroxamic acid-based histone deacetylase inhibitors
Authors: Rob De Vreese, Matthias D'hooghe
Pages: 174 - 195 - N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis
Authors: Rob De Vreese, Matthias D'hooghe
Pages: 398 - 402 - Selective synthesis of cis- and trans-2-(methyl/phenyl)-3-(trifluoromethyl)aziridines and their regio- and stereospecific ring opening
Authors: Matthias Moens, Norbert De Kimpe, Matthias D'hooghe
Pages: 5558 - 5568
Patents
1 - 2 of 2
- Selective HDAC6 inhibitors and uses thereof (Inventor)
- HDAC6 Inhibitors and uses thereof (Inventor)