Researcher
Matthew Holt
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Other biological sciences
- See also: Matthew Holt (Flanders Institute for Biotechnology)
Affiliations
- Laboratory of Glia Biology (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → 31 Jan 2022 - Holt Lab (Research group)
Responsible
From1 Jan 2017 → 31 Jan 2022 - Department of Human Genetics (Department)
Member
From1 Oct 2011 → 31 Dec 2016
Projects
11 - 20 of 34
- A role for astrocytes in conveying arousal effect in visual information processing.From1 Jan 2020 → 31 Dec 2020Funding: FWO research grant KAN
- Treating cognitive decline by targeting energy production in the central nervous system.From1 Oct 2019 → 30 Sep 2021Funding: BOF - projects
- Investigation of Adverse Health Effects Induced by Emerging Pollutants: Neurotoxicity of nanoparticles and Metal-related toxicity of E-cigarettesFrom1 Oct 2019 → 15 Oct 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- Decoding the mechanisms of neuronal wiring: a lesson from Trisomy 21From24 Sep 2019 → 24 Sep 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- A role for astrocytes in conveying arousal effect in visual information processing.From1 Oct 2018 → 30 Sep 2021Funding: FWO fellowships
- Mass cytometry by time-of-flight: next-generation flow cytometry for multiplexed single cell analysisFrom1 May 2018 → 30 Apr 2022Funding: FWO Medium Size Research Infrastructure
- Single-cell omics in high throughput and at spatial resolutionFrom1 May 2018 → 30 Apr 2022Funding: FWO Medium Size Research Infrastructure
- Targeted gene delivery as a novel therapeutic strategy to control inflammation in the CNSFrom15 Mar 2018 → 17 Oct 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- What is the effect of tau aggregation on synaptic function?From1 Dec 2017 → 5 Nov 2018Funding: Own budget, for example: patrimony, inscription fees, gifts
- Optimized AAV systems for vectored immunoprophylaxis as a therapeutic strategy to treat CNS related diseasesFrom4 Oct 2017 → 1 Sep 2022Funding: FWO Strategic Basic Research Grant
Publications
1 - 10 of 45
- Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's disease(2022)
Authors: Disha Shah, Willy Gsell, Jérôme Wahis, Emma Luckett, Ben Vermaercke, Pranav Preman, Daan Moechars, Mark Fiers, Matthew Holt, Dietmar Thal, et al.
- A conformational switch controlling the toxicity of the prion protein(2022)
Authors: Marika Marino, Matthew Holt
Pages: 831 - + - Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation(2022)
Authors: Lidia Yshii, Emanuela Pasciuto, Pierre Lemaitre, Marika Marino, James Dooley, Hannelore Kemps, Jérôme Wahis, Willy Gsell, Sebastian Munck, Robin Lemmens, et al.
Pages: 878 - + - Neurotoxicity of four frequently used nanoparticles: a systematic review to reveal the missing data(2022)
Authors: Matthew Holt, Peter Hoet, Manosij Ghosh
Pages: 1141 - 1212 - AAV Vector-Mediated Antibody Delivery (A-MAD) in the Central Nervous System(2022)
Authors: Marika Marino, Matthew Holt
- AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model(2022)
Authors: Marika Marino, Jérôme Wahis, Lidia Yshii, Catherine Marneffe, Maarten Dewilde, Adrian Liston, Bart De Strooper, Matthew Holt
- Localized astrogenesis regulates gyrification of the cerebral cortex(2022)
Authors: Matthew Holt
- Neurophotonic tools for microscopic measurements and manipulation: status report(2022)
Authors: Matthew Holt
- Star power: the emerging role of astrocytes as neuronal partners during cortical plasticity(2021)
Authors: Jérôme Wahis, Maroussia Hennes, Lut Arckens, Matthew Holt
Pages: 174 - 182 - AAV9-mediated gene delivery of MCT1 to oligodendrocytes does not provide a therapeutic benefit in a mouse model of ALS(2021)
Authors: Elisabeth Rossaert, Sebastian Munck, Philip Van Damme, Matthew Holt, Ludo Van Den Bosch, Wim Robberecht
Pages: 508 - 519
Patents
1 - 2 of 2
- Novel method (Inventor)
- Novel method (Inventor)