Researcher
Matthew Holt
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Other biological sciences
- See also: Matthew Holt (Flanders Institute for Biotechnology)
Affiliations
- Laboratory of Glia Biology (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → 31 Jan 2022 - Holt Lab (Research group)
Responsible
From1 Jan 2017 → 31 Jan 2022 - Department of Human Genetics (Department)
Member
From1 Oct 2011 → 31 Dec 2016
Projects
1 - 10 of 34
- Astrocytes dysfunctions in Phelan McDermid syndrome: from mechanisms towards new therapeutic strategiesFrom1 May 2022 → TodayFunding: FWO research project (including WEAVE projects)
- The astrocyte-specific proteome in inhibitory tripartite synapse formation and function in the context of Autism Spectrum DisorderFrom11 Jan 2022 → TodayFunding: FWO fellowships
- Investigating the role of astrocytes and noradrenaline as critical regulators of neuronal circuit excitability.From1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- The role of astrocytes (sub)types in adult brain plasticityFrom19 Nov 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Elucidating the role of astrocytes in noradrenaline-mediated seizure suppression and its possible therapeutic relevance for Alzheimer's disease.From1 Oct 2021 → TodayFunding: FWO senior postdoctoral fellowship
- Critical periods and brain plasticity – astrocytes as key modulators of cortical wiringFrom16 Aug 2021 → 8 Mar 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Investigating the contribution of astrocytes to experience-dependent cortical plasticity.From1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Connecting polyamine transport in astrocytes to neurodevelopmental disorders via ATP13A4From1 Oct 2020 → TodayFunding: FWO junior postdoctoral fellowship
- Cell subtype-specific neuron-glia contributions to cortical plasticityFrom1 Oct 2020 → TodayFunding: BOF - projects
- Integration of complementary, high throughput single-cell omics with spatial resolution.From1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
Publications
1 - 10 of 45
- Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's disease(2022)
Authors: Disha Shah, Willy Gsell, Jérôme Wahis, Emma Luckett, Ben Vermaercke, Pranav Preman, Daan Moechars, Mark Fiers, Matthew Holt, Dietmar Thal, et al.
- A conformational switch controlling the toxicity of the prion protein(2022)
Authors: Marika Marino, Matthew Holt
Pages: 831 - + - Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation(2022)
Authors: Lidia Yshii, Emanuela Pasciuto, Pierre Lemaitre, Marika Marino, James Dooley, Hannelore Kemps, Jérôme Wahis, Willy Gsell, Sebastian Munck, Robin Lemmens, et al.
Pages: 878 - + - Neurotoxicity of four frequently used nanoparticles: a systematic review to reveal the missing data(2022)
Authors: Matthew Holt, Peter Hoet, Manosij Ghosh
Pages: 1141 - 1212 - AAV Vector-Mediated Antibody Delivery (A-MAD) in the Central Nervous System(2022)
Authors: Marika Marino, Matthew Holt
- AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model(2022)
Authors: Marika Marino, Jérôme Wahis, Lidia Yshii, Catherine Marneffe, Maarten Dewilde, Adrian Liston, Bart De Strooper, Matthew Holt
- Localized astrogenesis regulates gyrification of the cerebral cortex(2022)
Authors: Matthew Holt
- Neurophotonic tools for microscopic measurements and manipulation: status report(2022)
Authors: Matthew Holt
- Star power: the emerging role of astrocytes as neuronal partners during cortical plasticity(2021)
Authors: Jérôme Wahis, Maroussia Hennes, Lut Arckens, Matthew Holt
Pages: 174 - 182 - AAV9-mediated gene delivery of MCT1 to oligodendrocytes does not provide a therapeutic benefit in a mouse model of ALS(2021)
Authors: Elisabeth Rossaert, Sebastian Munck, Philip Van Damme, Matthew Holt, Ludo Van Den Bosch, Wim Robberecht
Pages: 508 - 519
Patents
1 - 2 of 2
- Novel method (Inventor)
- Novel method (Inventor)